RecruitingPhase 2NCT07145229

Safety and Efficacy of ABP-745 in Participants With an Acute Gout Flare

A Randomized, Double-blind, Multicenter, Colchicine and Placebo-controlled Study to Evaluate the Efficacy and Safety of ABP-745 in Subjects With an Acute Gout Flare

Sponsor

Atom Therapeutics Co., Ltd

Enrollment

380 participants

Start Date

Aug 26, 2025

Study Type

INTERVENTIONAL

Conditions

Gout Flare Acute Gouty Arthritis Gout Flares Acute Gout Flare

Summary

A randomized, double-blind, international multicenter, colchicine and placebo-controlled study to evaluate the efficacy and safety of ABP-745 in subjects with acute gout. Efficacy of ABP-745 in reducing pain and swelling compared with standard colchicine treatment and placebo will be evaluated in participants with acute gout. The primary efficacy measurement will be pain score after treatment.

Eligibility

Min Age: 18 YearsMax Age: 70 Years

Plain Language Summary

Simplified for easier understanding

This clinical trial is studying a drug called ABP-745 Dose A, a drug called ABP-745 Dose B, and others for people with acute gout flare, acute gouty arthritis, and other related conditions. The study is currently recruiting participants at 38 locations. People eligible for this study include aged 18 Years to 70 Years.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGABP-745 Dose A

ABP-745 Dose A + Colchicine placebo - tablets (PO)

DRUGABP-745 Dose B

ABP-745 Dose B + Colchicine placebo - tablets (PO)

DRUGColchicine

ABP-745 placebo + Colchicine - tablets (PO)

DRUGPlacebo

ABP-745 placebo + Colchicine placebo - tablets (PO)

Locations(38)

Onyx Clinical Research

Peoria, Arizona, United States

Exinia Research

La Mesa, California, United States

Evergreen Clinical Trial

Norcross, Georgia, United States

Bioluminux Clinical Research

Naperville, Illinois, United States

Exinia Research

Des Moines, Iowa, United States

Northshore Research Associates

Alexandria, Louisiana, United States

DelRicht Research

Baton Rouge, Louisiana, United States

DelRicht Research

New Orleans, Louisiana, United States

Interphase Clinical Trials

Lutherville, Maryland, United States

DelRicht Research Gulfport

Gulfport, Mississippi, United States

Albuquerque Clinical Trials, Inc.

Albuquerque, New Mexico, United States

West Clinical Research

Morehead City, North Carolina, United States

DelRicht Research

Tulsa, Oklahoma, United States

Premier Family Physicians

Austin, Texas, United States

Emeritus Sydney

Botany, New South Wales, Australia

Canopy Clinical Research Northern Beaches

Brookvale, New South Wales, Australia

Novatrials

Kotara, New South Wales, Australia

Genesis Research Services

Newcastle, New South Wales, Australia

Emeritus Melbourne

Camberwell, Victoria, Australia

Canopy Clinical Research Altona North

North Altona, Victoria, Australia

Peking University Third hospital

Beijing, Beijing Municipality, China

Xuanwu Hospital Capital Medical University

Beijing, Beijing Municipality, China

The second affiliated hospital of guangxi medical university

Nanning, Guangxi, China

Hebei Petro China Central Hospital

Langfang, Hebei, China

Wuhan UHospital, Tongji Medical College, Huazhong University of Science and Technology

Wuhan, Hubei, China

Xiangtan Central Hospital

Xiangtan, Hunan, China

Xiangya Hospital Zhuzhou Central South University

Zhuzhou, Hunan, China

Huai'an First People's Hospital

Huai'an, Jiangsu, China

Pingxiang People's Hospital

Pingxiang, Jiangxi, China

Zaozhuang Municipal Hospital

Zaozhuang, Shandong, China

Huashan Hospital, Fudan University

Shanghai, Shanghai Municipality, China

Linfen Central hospital

Linfen, Shanxi, China

Shanxi Bethune Hospital

Taiyuan, Shanxi, China

Shaanxi Provincial People's Hospital

Xi’an, Shanxi, China

Xi'an Daxing Hospital

Xi’an, Shanxi, China

Chengdu Fifth People's Hospital

Chengdu, Sichuan, China

Hangzhou First People's Hospital

Hangzhou, Zhejiang, China

Wenzhou People's Hospital

Wenzhou, Zhejiang, China

View Full Details on ClinicalTrials.gov

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NCT07145229

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