No Sedation Versus Daily Interruption of Sedation in Chronic Obstructive Pulmonary Disease Mechanically Ventilated Patients- A Prospective Study

This study is comparing two approaches to sedation (calming medication) for COPD patients who are on a ventilator (breathing machine) in the ICU: giving no sedation versus briefly pausing sedation once a day. Researchers want to find out which approach is safer and more effective. **You may be eligible if...** - You are 18 years of age or older - You have been diagnosed with COPD (a chronic lung disease) - You are currently on a ventilator (breathing machine) in the ICU due to a COPD flare-up **You may NOT be eligible if...** - You have an allergy to the sedative medications used in the study - You have kidney or liver problems - You have a known psychiatric or neurological condition - You are pregnant Talk to your doctor to see if this trial is right for you.