RecruitingNot ApplicableNCT07147179

Short Course Radiotherapy

Pilot Trial of Short Course Radiotherapy for Primary or Secondary CNS Malignancies

Sponsor

Abramson Cancer Center at Penn Medicine

Enrollment

15 participants

Start Date

Apr 2, 2026

Study Type

INTERVENTIONAL

Conditions

Central Nervous System Cancer

Summary

This is a single arm prospective pilot trial determining the safety of short-course radiation therapy in pediatric patients with incurable central nervous system malignancies.

Eligibility

Max Age: 21 Years

Inclusion Criteria9

Male or female, aged 21 years or below
Lansky performance status >= 40
Has a diagnosis of an incurable malignancy that:
Originates outside the brain but is metastatic to 1 or more sites within the brain, or originates and recurs within the brain. For this diagnosis to be confirmed, there must be multidisciplinary review of up to date imaging at a pediatric tumor board with unanimous consensus of intracranial relapse or metastasis. If the consensus is not unanimous, short-interval repeat imaging with subsequent unanimous consensus would be required in order for this eligibility criteria to be met
Has at least 1 targetable intracranial lesion as seen on imaging
Has a multidisciplinary consensus recommendation for palliative intent radiation
Consents to the study or has caregiver who is able to provide signed and dated informed consent. For subjects under the age of 18, a signed and dated assent form as able.
Patients who had prior radiation in planned treatment area are also eligible to enter the trial
Stated willingness to comply with all study procedures and availability for the duration of the study

Exclusion Criteria3

Radiotherapy for curative intent
Serious uncontrolled systemic or psychiatric disorders that would interfere with participation in the protocol
Being planned for proton radiation

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