Hepatocellular Carcinoma Identification Using Delta-HLD

This study is testing whether a method called Delta-HLD can identify liver cancer (hepatocellular carcinoma, or HCC) using blood and tissue samples. Researchers will compare cancer patients with people who have liver cirrhosis (scarring) but no cancer. **You may be eligible if...** - You have a confirmed diagnosis of liver cancer (HCC), OR you have liver cirrhosis without cancer and can serve as a comparison participant - You are willing and able to provide paired blood and liver tissue samples **You may NOT be eligible if...** - You have another active cancer - You have had a liver transplant - You have a known hereditary cancer syndrome - You have received chemotherapy or antiviral treatment in the past 3 months Talk to your doctor to see if this trial is right for you.