RecruitingPhase 2NCT07149363

Adjuvant Chemotherapy and Immunotherapy for Completely Resected Small Cell Lung Cancer


Sponsor

Alliance Foundation Trials, LLC.

Enrollment

65 participants

Start Date

Feb 1, 2026

Study Type

INTERVENTIONAL

Conditions

Summary

This is a phase II trial of adjuvant chemotherapy and immunotherapy for completely resected small cell lung cancer (SCLC).


Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study is testing whether adding chemotherapy and immunotherapy after surgery improves outcomes for patients with small cell lung cancer (SCLC) that was completely removed surgically. Small cell lung cancer is an aggressive type that typically spreads quickly. **You may be eligible if...** - You are 18 years old or older and weigh more than 30 kg - You have a confirmed diagnosis of early-stage small cell lung cancer (T1-T2, N0-N1, no distant spread) - Your cancer was completely removed by surgery within the past 78 days - You have had complete lymph node removal or sampling during surgery - You have not previously received any systemic therapy for small cell lung cancer - Your expected life expectancy is at least 12 weeks **You may NOT be eligible if...** - Your cancer was not completely removed - You have received prior chemotherapy or immunotherapy for this cancer - Your overall health makes additional treatment unsafe Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGDurvalumab 50 MG/ML

Following surgical removal of their small-cell lung cancer, participants will receive a combination of 1500 mg durvalumab and cisplatin 75 mg/m2 or carboplatin AUC 5 on day 1, and etoposide 100 mg/m2 on days 1, 2, and 3, every 3 weeks for 4 cycles (a total of 12 weeks). Following the combination of chemotherapy and immunotherapy, participants will then receive 1500 mg durvalumab every 4 weeks for 9 cycles (a total of 36 weeks).


Locations(1)

University of Virginia Comprehensive Cancer Center

Charlottesville, Virginia, United States

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NCT07149363


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