Anti-inflammatory Activities of Vitamin C Supplementation on the Gut Barrier Function in Adults With Obesity

This study is looking at whether taking vitamin C supplements can reduce inflammation and improve gut health in adults who are overweight or obese. Participants will take vitamin C supplements while temporarily eating a diet low in fruits and vegetables. **You may be eligible if...** - You are between 18 and 50 years old - You are English-speaking - Your BMI is between 30 and 40 - Your resting blood pressure is below 140/90 mmHg - You have not taken multivitamins or vitamin C supplements in the past month - You eat meat (not vegetarian or vegan) - You are willing to follow a low fruit-and-vegetable diet for two 2-week periods **You may NOT be eligible if...** - You currently smoke or vape (tobacco, cannabis, or nicotine products) - You drink more than 2 alcoholic drinks per day - You have used antibiotics, probiotic supplements, or anti-inflammatory drugs in the past month - You have uncontrolled diabetes, high cholesterol, or high blood pressure - You have a history of bleeding disorders, hemochromatosis, or kidney stones - You are pregnant, breastfeeding, or recently changed birth control (women) - You take blood thinners, certain antiviral drugs, or certain antipsychotic medications that interact with vitamin C Talk to your doctor to see if this trial is right for you.