Efficacy of Combined Fractional Er:Glass and Thulium Lasers Versus Microneedling for Atrophic Acne Scars
Randomized Controlled Trial Comparing Fractional Erbium:Glass (1540-1550 nm) and Thulium (1927 nm) Lasers Versus Microneedling for the Treatment of Atrophic Acne Scars
University of Nove de Julho
84 participants
Oct 16, 2025
INTERVENTIONAL
Conditions
Summary
The purpose of this study is to compare two treatments for acne scars on the face. The study will test whether fractional lasers (Erbium:Glass and Thulium) lead to better improvement in acne scars than microneedling.
Eligibility
Inclusion Criteria2
- Fitzpatrick skin phototypes I to VI
- Presence of atrophic acne scars on the face
Exclusion Criteria10
- Decompensated systemic diseases
- Any active infection (e.g., viral such as herpes, bacterial, or fungal)
- Pregnant or breastfeeding women
- Presence of hypertrophic or keloid scars
- Current use of anticoagulant or antiplatelet medications
- History of hemophilia or coagulation disorders
- Current use of anti-inflammatory drugs or corticosteroids
- Use of retinoids, including isotretinoin, within the past 6 months
- Exposure to sunlight within the past 15 days
- Undergoing any aesthetic facial treatment or having undergone scar treatments in the facial region within 180 days prior to study initiation
Interested in this trial?
Get notified about updates and connect with the research team.
Interventions
Microneedling performed with an electronic pen and sterile disposable cartridge with 12 needles and 2mm depth, three treatment sessions at four-week intervals.
Fractional Erbium:Glass laser will be applied first, focused on scarred areas (50 mJ, 15 ms e 100 PPA) , followed immediately by fractional Thulium 1927 nm over the full face (10 mJ, 1 ms e 100 PPA), three treatment sessions at four-week intervals.
Locations(1)
View Full Details on ClinicalTrials.gov
For the most up-to-date information, visit the official listing.
NCT07151599