Impact of Plant Proteins and Exercise on Protein Metabolism in Older Adults
Innovative Plant Proteins Fibre and Physical Activity Solutions to Modulate Whole Body and Skeletal Muscle Protein Metabolism in Older Adults
University Hospital, Clermont-Ferrand
12 participants
Aug 26, 2025
INTERVENTIONAL
Conditions
Summary
To gain mechanistic insights by examining the impact of innovative plant-protein fibre products, physical activity interventions on digestibility, amino acid bioavailability and whole-body protein metabolism in older persons
Eligibility
Inclusion Criteria4
- BMI 22-30 kg/m²
- Inactive (<150 minutes of moderate to vigorous physical activity per week and no regular resistance training),
- Covered by a social security system
- Agrees to undergo the study interventions (undirect calorimetry, functional tests, physical activity program)
Exclusion Criteria18
- Hamilton HAD scale with a score > 9
- Subject with a pathology or treatment (diabetic on insulin, corticosteroids > 8 days, neuroleptics, anticoagulant, antiplatelet) judged by the investigator as incompatible with the study
- Subject with unstabilized thyroid dysfunction for at least 3 months
- Subject with unstabilized hypertension for at least 3 months
- Subject with a medical and/or surgical history judged by the investigator as incompatible with the trial
- More than 21 alcoholic drinks per week
- Heavy smoker (>10 cigarettes/day)
- Currently participating in another intervention study
- Absence of informed consent
- Inability to participate in physical activity
- Allergy(ies) or refusal to consume one of the foods tested as part of the the study
- Allergy to local anesthetics
- Declared glaucoma
- Prostate hypertrophy
- Refusal to register in the national file of volunteers who participate in research involving human beings
- Subject in a period of exclusion from a previous study or having received a total amount of compensation greater than 6,000 euros over the 12 months preceding the start of the trial (after verification in the File of Volunteers for Research involving Human Beings)
- Patients under guardianship, curatorship, deprived of liberty or legal protection
- Subject with claustrophobia
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Interventions
The 12 week intervention will involve 2 weekly group exercise sessions incorporating strength and balance exercises, along with home-based exercise focused on increasing time spent walking.
Locations(1)
View Full Details on ClinicalTrials.gov
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NCT07155824