Neurofeedback to Treat Depression - 2

This study tests neurofeedback — a technique where people learn to control their own brain activity in real-time using MRI feedback — as a treatment for depression. Unlike medication, neurofeedback trains the brain directly without drugs, and this trial tests whether it can reduce depressive symptoms. **You may be eligible if...** - You are between 18 and 65 years old - You have been diagnosed with Major Depressive Disorder (MDD) or Bipolar II depression - Your depression score is at least 16 on the MADRS scale (indicating significant symptoms) - You are not currently taking any psychiatric medications or receiving therapy - You can read and understand English **You may NOT be eligible if...** - You are pregnant - You have a metal implant or severe claustrophobia (MRI contraindications) - You have a neurological disorder, psychotic disorder, or active substance abuse - You are currently taking antidepressants or other psychiatric medications Talk to your doctor to see if this trial is right for you.