Personalized Theta-burst Stimulation for Long-lasting Changes in Approach/Avoidance Behavior
The Efficiency of Personalized Theta-burst Stimulation for Inducing Long-lasting Changes in DLPFC
Northwestern University
26 participants
Jul 31, 2025
INTERVENTIONAL
Conditions
Summary
This study will assess the long-lasting effects of personalized theta burst stimulation (TBS), a repetitive form of transcranial magnetic stimulation (TMS), over the left prefrontal cortex on the approach/avoidance behavior. TBS will be personalized based on the prefrontal theta rhythm captured with electroencephalography (EEG). The main questions it aims to answer are: 1. does a single session of personalized TBS synchronized with the individual theta rhythm over the left prefrontal cortex results in the outlasting changes in the individual behavior? 2. Does TBS results in the brain rhythms' changes as measured using resting-state EEG?
Eligibility
Inclusion Criteria2
- Participants must be legal adults between the ages of 18 to 65;
- Able and willing to complete study procedures and tasks.
Exclusion Criteria6
- History or evidence of chronic neurological or mental disorder;
- Chronic condition that requires pharmacological treatment over the course of study participation;
- Pregnancy or breastfeeding;
- History or evidence of alcohol or drug addiction;
- Contraindications for transcranial magnetic stimulation (history of seizures, metallic or electric implant in the head/neck area);
- Contraindications for magnetic resonance imaging at 3 Tesla (non-compatible implants, metallic foreign bodies, insulin pump, pacemaker).
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Interventions
Theta-burst stimulation (TBS) over the left dorsolateral prefrontal cortex (DLPFC) synchronized with the ongoing electroencephalographic (EEG) oscillations in the theta (3-7 Hz) range at a suprathreshold pulse intensity (up to 120% rMT).
Theta-burst stimulation (TBS) over the postcentral gyrus, synchronized with the ongoing electroencephalographic (EEG) oscillations in the theta (3-7 Hz) range at a suprathreshold pulse intensity (up to 120% rMT).
Theta-burst stimulation (TBS) over the left dorsolateral prefrontal cortex (DLPFC) at a suprathreshold pulse intensity (up to 120% rMT).
Theta-burst stimulation (TBS) similar to the "TBS-EEG" condition but at a subthreshold pulse intensity (up to 80% rMT).
Locations(1)
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NCT07161505