A Study on the Modulation of Gut Microbiota by Oral Sialic Acid in Healthy Subjects
Modulation of Gut Microbiota by Oral Sialic Acid: A Mechanistic Study
Xiaolong Li
42 participants
Sep 10, 2025
INTERVENTIONAL
Conditions
Summary
This is a single-center prospective cohort study conducted by the Department of General Surgery at the Second Affiliated Hospital of Army Medical University (Xinqiao Hospital). The purpose of this study is to explore and clarify the effects of sialic acid intervention on gut microbiota structure, with a focus on the proliferation of pathogens (e.g., Escherichia coli, Klebsiella pneumoniae), and to develop novel prevention and treatment strategies for improving intestinal homeostasis.
Eligibility
Inclusion Criteria4
- Aged between 18 and 75 years
- No history of major diseases, no previous surgical history, and no history of cardiometabolic diseases (such as hypertension, diabetes mellitus, obesity, etc.)
- No use of drugs that may affect gut microbiota or metabolic function (e.g., antibiotics, probiotics, immunosuppressants, etc.);
- Voluntarily participate in the study and sign the informed consent form.
Exclusion Criteria4
- Comorbidities: Complicated with other severe diseases (e.g., immunodeficiency, chronic liver disease, renal insufficiency, malignant tumors, etc.).
- Recent infections: Registration records indicate a history of severe infections in the recent period (within 3 months) or currently receiving anti-infective treatment.
- Special populations: Pregnant women, lactating women, or women planning to become pregnant.
- Poor compliance: Volunteers who are unable to cooperate with the study protocol or follow-up
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Interventions
This study employs a before-after self-control trial design, recruiting 42 volunteers to take oral sialic acid and collecting fecal samples before and after the intervention.
Locations(1)
View Full Details on ClinicalTrials.gov
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NCT07162662