RecruitingNCT07166003

Efficacy of Neoadjuvant Immunotherapy in Patients With Lung Cancer

Effects of Neoadjuvant Immunotherapy on Patients With Lung Cancer: a Prospective, Observational Study


Sponsor

Cancer Institute and Hospital, Chinese Academy of Medical Sciences

Enrollment

500 participants

Start Date

Apr 20, 2025

Study Type

OBSERVATIONAL

Conditions

Summary

The goal of this observational study is to learn about the long-term effects of neoadjuvant immunotherapy in patients with lung cancer. The main questions it aims to answer are: * Does pneumonectomy bring more benefits for pateints than lobectomy? * Does surgery bring more benefits for patients than non-surgery modalities (such as radiotherapy) after neoadjuvnat immunotherapy? Participants will receive neoadjuvant treatment and the study will analyze the data.


Eligibility

Min Age: 18 YearsMax Age: 79 Years

Plain Language Summary

Simplified for easier understanding

This study is reviewing patient records to understand how well immunotherapy given before lung cancer surgery (called neoadjuvant immunotherapy) actually works in real-world patients. Researchers are looking at scans, treatment histories, and outcomes to identify who responds best. **You may be eligible if...** - You are between 18 and 79 years old - You have lung cancer and received at least two rounds of immunotherapy before surgery - You were in excellent health at the time of treatment (ECOG performance status of 0) - You have complete medical records including imaging scans **You may NOT be eligible if...** - You have or are suspected to have an active autoimmune disease - Your lung cancer has certain genetic mutations (EGFR or ALK) - You are pregnant or breastfeeding - You had prior chemotherapy or radiation for your cancer - You have had an organ or stem cell transplant - You have serious lung disease, uncontrolled diabetes, or uncontrolled high blood pressure Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

PROCEDUREPneumonectomy

Patients will receive pneumonectomy after neoadjuvant treatment

PROCEDURElobectomy

Patients will receive lobectomy after neoadjuvant immunotherapy.

RADIATIONradiotherapy

Patients will receive radiotherapy after neoadjuvant immunotherapy.

DRUGAnti-Tumor Drugs

Patients will receive anti-tumor drugs.


Locations(1)

Cancer Hospital Chinese Academy of Medical Sciences

Beijing, China

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NCT07166003


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