RecruitingNot ApplicableNCT07167056

Artificial Intelligence-Powered Support For Quality Of Life Improvement In Participants With Cancer

Artificial Intelligence-Powered Support For Quality Of Life Improvement In Patients With Cancer

Sponsor

Case Comprehensive Cancer Center

Enrollment

60 participants

Start Date

Nov 17, 2025

Study Type

INTERVENTIONAL

Conditions

Cancer

Summary

This research study is for people who are diagnosed with cancer and are receiving treatment for cancer who may benefit from psychotherapy. The purpose of the study is to see whether an artificial intelligence (AI) powered application (app) could help improve quality of life, anxiety symptoms, and/or depression symptoms, over the course of psychotherapy sessions. Participants in this study will be randomly assigned to one of two groups. One group will receive psychotherapy per usual care and will receive access to the AI-powered app. The second group will only receive psychotherapy per usual care and will NOT receive access to the AI-powered app. Both groups will complete surveys about their quality of life, anxiety symptoms, and depression symptoms over the course of their psychotherapy visits.

Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study is testing whether an AI-powered support tool can improve quality of life and reduce psychological distress in cancer patients undergoing active treatment. The AI tool is designed to provide personalized emotional and practical support between clinic visits. **You may be eligible if...** - You are currently in active cancer treatment (chemotherapy, immunotherapy, and/or radiation therapy) - You have reported significant emotional distress (score of 4 or higher on the NCCN Distress Thermometer) - You are followed by an oncologist at Cleveland Clinic Florida - You have no insurance barriers to receiving psychotherapy care - You have been confirmed to have cancer by biopsy **You may NOT be eligible if...** - You are not currently in active treatment - Your distress score is below the clinical threshold - You have insurance restrictions preventing psychotherapy access - You are unable to use a digital device or give informed consent Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

BEHAVIORALStandard of Care Psychotherapy

Participants will receive six psychotherapy sessions over the course of approximately 3 months.

BEHAVIORALWYSA App

Participants will have access to the WYSA mental health support artificial intelligence app over the course of the 3 months that they are participating in psychotherapy sessions per standard of care. The app will contain features intended to manage symptoms of depression and anxiety in individuals with cancer. The app will include an AI-powered chatbot with Cognitive Behavioral Therapy (CBT) and mindfulness techniques, visual progress elements (a progress roadmap, a weekly progress report, etc.), and a customizable tool library. Participants are instructed to use the app whenever they feel like it, if they are in distress, or if the app prompts them to use it. App prompts (notifications) will occur once daily.