Study of PSMA PET/CT Imaging to Help Select Men With Low-Risk Prostate Cancer for Active Surveillance

This study is investigating whether a specialized type of scan called PSMA PET/CT — which highlights prostate cancer cells very precisely — can help doctors identify which men with low-risk prostate cancer are truly safe to monitor with active surveillance (watchful waiting without immediate treatment) instead of surgery or radiation. **You may be eligible if...** - You are a man with low-risk prostate cancer confirmed by biopsy (grade group 1) - Your PSA level is 10 ng/mL or below - Your cancer appears to be early-stage (up to T2a on imaging) - You have no more than 3 positive biopsy cores - You have a life expectancy of at least 10 years - You have had an MRI and prostate biopsy recently **You may NOT be eligible if...** - Your cancer is intermediate or high risk - You have already had any prostate cancer treatment or surgery - Imaging shows cancer has spread outside the prostate - You have had a prior PSMA PET scan Talk to your doctor to see if this trial is right for you.