Colon Cancer Liquid Biopsy Investigation of Methylation-based Biomarkers Evaluation Using Delta-HLD (CLIMBED)

This study (CLIMBED) is testing a new blood-based test — called a liquid biopsy — that looks for cancer-related chemical changes in DNA in the bloodstream to detect colon cancer or pre-cancerous polyps. This non-invasive test could eventually offer an alternative or companion to colonoscopy for colorectal cancer screening. **You may be eligible if...** - You are between 45 and 75 years old - Your doctor has recommended that you have a colonoscopy for routine colorectal cancer screening **You may NOT be eligible if...** - You have a first-degree family member (parent, sibling, child) with colorectal cancer - You have inflammatory bowel disease (Crohn's disease or ulcerative colitis) - You have had another cancer within the past 5 years - You have a known hereditary colorectal cancer syndrome (such as Lynch syndrome or FAP) - You have had major surgery, trauma, or a blood transfusion in the past 30 days - You are currently enrolled in another interventional clinical trial Talk to your doctor to see if this trial is right for you.