RecruitingPhase 1Phase 2NCT07169500

Clinical Study on the Safety and Efficacy of BCMA-CART±ASCT in Treating Young Multiple Myeloma Patients


Sponsor

Institute of Hematology & Blood Diseases Hospital, China

Enrollment

50 participants

Start Date

Mar 3, 2025

Study Type

INTERVENTIONAL

Conditions

Summary

Evaluate and compare the safety and efficacy of BCMA-CART ± ASCT in the treatment of newly diagnosed multiple myeloma (NDMM) in young patients


Eligibility

Min Age: 18 YearsMax Age: 50 Years

Plain Language Summary

Simplified for easier understanding

This trial is studying the safety and effectiveness of BCMA-CAR T-cell therapy — an advanced immune cell treatment that targets a protein on myeloma cells — with or without a stem cell transplant in young women with multiple myeloma. Multiple myeloma is a blood cancer that affects plasma cells in the bone marrow. **You may be eligible if...** - You are a woman between 18 and 55 years old - You have been confirmed to have multiple myeloma by testing - Your organ function (liver, kidneys, blood clotting) meets required levels - You are willing to participate and provide informed consent **You may NOT be eligible if...** - You are male (this study is specifically in young women) - You are over 55 years old - You have severe organ dysfunction - You are pregnant or breastfeeding - You have an active uncontrolled infection or another serious illness Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

BIOLOGICALCAR-T

Chimeric antigen receptor T cells (car-t) are genetically engineered MHC independent tumor specific killer cells.


Locations(1)

Institute of Hematology & Blood Diseases Hospital

Tianjin, Tianjin Municipality, China

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NCT07169500


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