RecruitingNCT07169656

Observation Study on Reducing the Risk of Liver Cancer Associated With Hepatitis B (Zhiyuan) Project.

Sponsor

The First Affiliated Hospital of Zhengzhou University

Enrollment

15,000 participants

Start Date

Jun 3, 2024

Study Type

OBSERVATIONAL

Summary

This study is a multicenter, prospective, observational real-world study designed to investigate and analyze the current treatment patterns of chronic hepatitis B (CHB) across 200 hospitals in China. By comparing patient outcomes under different therapeutic regimens, it aims to provide high-quality evidence-based medical data to optimize CHB treatment strategies and follow-up protocols, ultimately contributing to the advancement of a functional cure for chronic hepatitis B.

Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This observational study (Zhiyuan Project) is following patients with chronic hepatitis B — a long-term liver virus infection — who are receiving antiviral medications to see how well these treatments reduce the risk of developing liver cancer (hepatocellular carcinoma) over time. No experimental treatment is involved. **You may be eligible if...** - You have chronic hepatitis B (HBsAg-positive for at least 6 months) - You are 18 years or older - You are already receiving or about to start treatment with one of several approved antiviral medications (entecavir, tenofovir, or pegylated interferon) - You have provided written consent **You may NOT be eligible if...** - You have severe liver dysfunction or decompensated cirrhosis (advanced liver failure) - You are already enrolled in another clinical trial - You have been diagnosed with liver cancer (hepatocellular carcinoma) Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGETV,TDF,TAF,TMF

treated with entecavir (ETV), tenofovir disoproxil fumarate (TDF), tenofovir alafenamide fumarate (TAF), or tenofovir amibufenamide (TMF)

DRUGPeginterferon α-2b injection

treated with Peginterferon α-2b injection

Locations(162)

Huaxian People's Hospital

Anyang, China

Linzhou City People's Hospital

Anyang, China

Neihuang County People's Hospital

Anyang, China

Tangyin County People's Hospital

Anyang, China

The Fifth People's Hospital of Anyang

Anyang, China

The First Affiliated Hospital of Xinxiang Medical University (Hua County Branch)

Anyang, China

Guangzhou First People's Hospital

Guangzhou, China

The First Affiliated Hospital of Jinan University (Guangzhou Overseas Chinese Hospital)

Guangzhou, China

Hebi Coal Mining Group General Hospital

Hebi, China

Hebi Infectious Disease Hospital

Hebi, China

Junxian County People's Hospital

Hebi, China

Bo'ai County People's Hospital

Jiaozuo, China

Mengzhou Hospital of Traditional Chinese Medicine

Jiaozuo, China

Qinyang People's Hospital

Jiaozuo, China

The Secend People's Hospital of Jiaozuo

Jiaozuo, China

The Third People's Hospital of Jiaozuo

Jiaozuo, China

Xiuwu People's Hospital

Jiaozuo, China

Wenxian People's Hospital

Jiayuguan, China

Jiyang County Hospital of Traditional Chinese Medicine

Jinan, China

Shandong Public Health Clinical Center

Jinan, China

Jiyuan People's Hospital

Jiyuan, China

Jiyuan Traditional Chinese Medicine Hospital

Jiyuan, China

Huaihe Hospital of Henan University

Kaifeng, China

Infectious Diseases Hospital of Kaifeng

Kaifeng, China

Kaifeng Central Hospital

Kaifeng, China

Kaifeng Hospital of Traditional Chinese Medicine

Kaifeng, China

Lankao First Hospital Group

Kaifeng, China

Qixian People's Hospital

Kaifeng, China

The People's Hospital of Weishi

Kaifeng, China

Tongxu County People's Hospital

Kaifeng, China

Weishi County People's Hospital

Kaifeng, China

Linyi Hospital of Traditional Chinese Medicine

Linyi, China

Linyi People's Hospital

Linyi, China

Linying County People's Hospital

Luohe, China

Luohe Central Hospital

Luohe, China

Luanchuan County People's Hospital

Luoyang, China

Luoning County People's Hospital

Luoyang, China

Luoyang Central Hospital

Luoyang, China

Luoyang First People's Hospital

Luoyang, China

Luoyang Third People's Hospital

Luoyang, China

Ruyang County People's Hospital

Luoyang, China

The First Affiliated Hospital of Henan University of Science and Technology

Luoyang, China

Xin'an County People's Hospital

Luoyang, China

Yichuan County Hospital of Traditional Chinese Medicine

Luoyang, China

Yiyang County People's Hospital

Luoyang, China

Dengzhou Central Hospital

Nanyang, China

Dengzhou People's Hospital

Nanyang, China

Fangcheng County People's Hospital

Nanyang, China

Nanyang Central Hospital

Nanyang, China

Nanyang First People's Hospital

Nanyang, China

Nanyang Oilfield General Hospital

Nanyang, China

Nanyang Second General Hospital

Nanyang, China

Nanzhao County People's Hospital

Nanyang, China

Neixiang County People's Hospital

Nanyang, China

Sheqi County People's Hospital

Nanyang, China

Tanghe County People's Hospital

Nanyang, China

The First Affiliated Hospital of Nanyang Medical College

Nanyang, China

Xinye County People's Hospital

Nanyang, China

Xixia County People's Hospital

Nanyang, China

Zhenping People's Hospital

Nanyang, China

Ningbo Medical Center Iihuili hospital

Ningbo, China

General Hospital Of Pingmei Shenma Group

Pingdingshan, China

Lushan County People's Hospital

Pingdingshan, China

People's Hospital of Baofeng

Pingdingshan, China

Pingdingshan First People's Hospital

Pingdingshan, China

Ruzhou First People's Hospital

Pingdingshan, China

Ye County People's Hospital

Pingdingshan, China

Pingdu Municipal People's Hospital

Pingdu, China

Anyang District Hospital

Pujiang, China

Chinese Medicine Hospital of puyang

Pujiang, China

Fanxian People's Hospital

Pujiang, China

Nanle County People's Hospital

Pujiang, China

Puyang People's Hospital

Pujiang, China

The Fifth People's Hospital of Puyang City

Pujiang, China

People's Hospital of Rizhao

Rizhao, China

Huanghe Sanmenxia Hospital

Sanmenxia, China

Sanmenxia Central Hospital

Sanmenxia, China

The First People's Hospital of Lingbao

Sanmenxia, China

The Sixth People's Hospital of Lingbao

Sanmenxia, China

Yimei Group General Hospital

Sanmenxia, China

Minquan County Hospital of Traditional Chinese Medicine

Shangqiu, China

Minquan County People's Hospital

Shangqiu, China

Second People's Hospital Xiayi Country

Shangqiu, China

Shangqiu Fourth People's Hospital

Shangqiu, China

Shangqiu Hospital of Traditional Chinese Medicine

Shangqiu, China

Shangqiu Municipal Hospital

Shangqiu, China

Shangqiu Third People's Hospital

Shangqiu, China

Sui County People's Hospital

Shangqiu, China

Suixian County Hospital of Traditional Chinese Medicine

Shangqiu, China

The First People's Hospital of Shangqiu

Shangqiu, China

The People's Hospital of Yucheng County

Shangqiu, China

Xiayi County People's Hospital

Shangqiu, China

Yongcheng Central Hospital

Shangqiu, China

Yucheng County People's Hospital

Shangqiu, China

Zhecheng People's Hospital

Shangqiu, China

Zhecheng Traditional Chinese Medicine Hospital Co., Ltd.

Shangqiu, China

Changyuan County People's Hospital

Xinxiang, China

Huixian People's Hospital

Xinxiang, China

The First Affiliated Hospital of Xinxiang Medical University

Xinxiang, China

The Third Affiliated Hospital of Xinxiang Medical University

Xinxiang, China

Xinxiang First People's Hospital

Xinxiang, China

Xinxiang Infectious Disease Hospital

Xinxiang, China

Yanjin County People's Hospital

Xinxiang, China

Guangshan County People's Hospital

Xinyang, China

Gushi County People's Hospital

Xinyang, China

Huaibin County People's Hospital

Xinyang, China

Huangchuan County People's Hospital

Xinyang, China

Luoshan County People's Hospital

Xinyang, China

Xinyang Central Hospital

Xinyang, China

Xinyang Specialized Hospital for Infectious Diseases

Xinyang, China

Xixian People's Hospital

Xinyang, China

Changge People's Hospital

Xuchang, China

Xiangcheng County Traditional Chinese Medicine Hospital

Xuchang, China

Xiangcheng People's Hospital

Xuchang, China

Xuchang Central Hospital

Xuchang, China

Xuchang People's Hospital

Xuchang, China

Yanling County People's Hospital

Xuchang, China

Yanling County Traditional Chinese Medicine Hospital

Xuchang, China

Yuzhou Central Hospital

Xuchang, China

Yuzhou City People's Hospital

Xuchang, China

Chinese People's Liberation Army Joint Logistics Support Force 970 Hospital,

Yantai, China

Jiaozuo People's Hospital

Yantai, China

Yantai Qishan Hospital

Yantai, China

Gongyi City People's Hospital

Zhengzhou, China

The First Affiliated Hospital of Henan University of Chinese Medicine

Zhengzhou, China

The First Affiliated Hospital of Zhengzhou University

Zhengzhou, China

The First People's Hospit of Zhengzhou

Zhengzhou, China

The Second Affiliated Hospital of Zhengzhou University

Zhengzhou, China

The Six People's Hospit of Zhengzhou

Zhengzhou, China

The Third People's Hospit of Zhengzhou

Zhengzhou, China

Third Affiliated Hospital of Henan University of Traditional Chinese Medicine

Zhengzhou, China

Xingyang People's Hospital

Zhengzhou, China

Zhengzhou Central Hospital

Zhengzhou, China

Zhengzhou Traditional Chinese Medicine Hospital

Zhengzhou, China

Zhongmu County Hospital of Traditional Chinese Medicine

Zhengzhou, China

Zhongmu County People's Hospital

Zhengzhou, China

Zhongshan Second People's Hospital

Zhongshan, China

Dancheng County People's Hospital

Zhoukou, China

Fugou County People's Hospital

Zhoukou, China

Shenqiu People's Hospital

Zhoukou, China

Taikang County People's Hospital

Zhoukou, China

The Frist People's Hospital Of Xiangcheng

Zhoukou, China

The People's Hospital Of Luyi

Zhoukou, China

Xihua County Hospital of Traditional Chinese Medicine

Zhoukou, China

Xihua County People's Hospital

Zhoukou, China

Zhoukou Central Hospital

Zhoukou, China

Zhoukou Hospital Of TCM

Zhoukou, China

Zhoukou Specialized Disease Hospital

Zhoukou, China

People's Hospital of Queshan

Zhumadian, China

Pingyu County People's Hospital

Zhumadian, China

Runan County Hospital of Traditional Chinese Medicine

Zhumadian, China

Shangcai County People's Hospital

Zhumadian, China

The 990th Hospital of the Joint Logistics Support Force of the PLA

Zhumadian, China

The People's Hospital Of Biyang Country

Zhumadian, China

Xincai County People's Hospital

Zhumadian, China

Xincai Medical University

Zhumadian, China

Xiping County People's Hospital

Zhumadian, China

Zhengyang County People's Hospital

Zhumadian, China

Zhumadian Central Hospital

Zhumadian, China

Zhumadian Traditional Chinese Medicine Hospital

Zhumadian, China

Zibo Central Hospital

Zibo, China

Zibo Infectious Diseases Hospital (Zibo Fourth People's Hospital)

Zibo, China

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NCT07169656