RecruitingPhase 2NCT07169851

A Study to Evaluate LY3537021 for the Treatment of Nausea and Vomiting Caused by Chemotherapy in Adults With Cancer

A Phase 2, Double-blind, Placebo-Controlled Study to Evaluate LY3537021 for the Treatment of Chemotherapy-Induced Nausea and Vomiting in Adult Participants With Malignant Disease

Sponsor

Eli Lilly and Company

Enrollment

204 participants

Start Date

Nov 28, 2025

Study Type

INTERVENTIONAL

Conditions

Neoplasms Vomiting Nausea Drug-Related Side Effects and Adverse Reactions

Summary

The purpose of this study is to check how well LY35327021 works and how safe it is for controlling nausea and vomiting caused by chemotherapy. Participants who join this study will be in it until all parts are finished, which could take about 2 months.

Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This clinical trial is studying a drug called Background Chemotherapy, a drug called LY3537021, and others for people with drug-related side effects and adverse reactions, nausea, and other related conditions. The study is currently recruiting participants at 67 locations. People eligible for this study include aged 18 Years and older.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGLY3537021

Administered SC

DRUGPlacebo

Administered SC

DRUGStandard of Care Antiemetic Therapies

5-HT3 Receptor Antagonist, NK1 Receptor Antagonist, Dexamethasone administered orally, IV, or transdermally

DRUGBackground Chemotherapy

Cisplatin or anthraxyline and cyclophosphamide (AC) administered IV

Locations(67)

Marin Cancer Care

Greenbrae, California, United States

City of Hope Orange County Lennar Foundation Cancer Center

Irvine, California, United States

Cancer and Blood Specialty Clinic

Los Alamitos, California, United States

BASS Cancer Center

Walnut Creek, California, United States

UCHealth Harmony

Fort Collins, Colorado, United States

Clavis Medical

Miami Lakes, Florida, United States

BRCR Global - Tamarac

Tamarac, Florida, United States

Summit Cancer Care, PC

Savannah, Georgia, United States

Hope and Healing Cancer Services

Hinsdale, Illinois, United States

Indiana University Melvin and Bren Simon Cancer Center

Indianapolis, Indiana, United States

North Mississippi Hematology and Oncology Associates

Tupelo, Mississippi, United States

Laura and Isaac Perlmutter Cancer Center

New York, New York, United States

New York Cancer and Blood Specialists

Shirley, New York, United States

Oncology Specialists of Charlotte

Charlotte, North Carolina, United States

Southern Oncology Specialists

Huntersville, North Carolina, United States

Asante Rogue Regional Medical Center

Medford, Oregon, United States

World Research Link

Baytown, Texas, United States

John Peter Smith Hospital

Fort Worth, Texas, United States

Community Cancer Trials of Utah

Ogden, Utah, United States

Cancer Care Northwest

Spokane, Washington, United States

Ballarat Health Services

Ballarat Central, Australia

Bendigo Health Care Group

Bendigo, Australia

WA Country Health Service Trial Centre

Perth, Australia

Goulburn Valley Health

Shepparton, Australia

Latrobe Regional Health

Traralgon, Australia

The First People's Hospital of Changde City

Changde, China

Zhujiang Hospital

Guangzhou, China

Zhejiang Provincial People's Hospital

Hangzhou, China

Jiangmen Center Hospital

Jiangmen, China

The First Affiliated Hospital of Henan University of Science &Technology

Luoyang, China

Sainte Catherine Institut du Cancer Avignon Provence

Avignon, France

Centre Hospitalier d'Annecy

Epagny Metz-Tessy, France

Clinique Victor Hugo Le Mans

Le Mans, France

Aou Ospedali Riuniti Umberto I

Ancona, Italy

Azienda Ospedaliero Universitaria

Modena, Italy

Azienda Ospedaliera Universitaria Pisana

Pisa, Italy

AULSS8 Berica-Ospedale S.Bortolo

Vicenza, Italy

Himeji Medical Center

Himeji, Japan

The Cancer Institute Hospital of JFCR

Kōtoku, Japan

Kyoto University Hospital

Kyoto, Japan

Shizuoka Cancer Center

Nagaizumi-cho,Sunto-gun, Japan

SC Memorial Healthcare International SRL

Bucharest, Romania

Spitalul Clinic Colentina

Bucharest, Romania

Spitalul Clinic Colțea

Bucharest, Romania

Centrul de Oncologie "Sfântul Nectarie"

Craiova, Romania

Ovidius Clinical Hospital OCH

Ovidiu, Romania

Hospital de la Santa Creu i Sant Pau

Barcelona, Spain

FutureMeds - Madrid

Madrid, Spain

Hospital General Universitario Gregorio Marañon

Madrid, Spain

Hospital Universitario Fundación Jiménez Díaz

Madrid, Spain

Hospital de Mataró

Mataró, Spain

Hospital Universitario Virgen de la Victoria

Málaga, Spain

Hospital Universitari Sant Joan de Reus

Reus, Spain

E-Da Cancer Hospital

Kaohsiung City, Taiwan

National Cheng Kung University Hospital

Tainan, Taiwan

Chi Mei Hospital - Liouying Branch

Tainan, Taiwan

Taipei Veterans General Hospital

Taipei, Taiwan

Chang Gung Medical Foundation-Linkou Branch

Taoyuan, Taiwan

Adana Medical Park Seyhan Hastanesi

Adana, Turkey (Türkiye)

Ankara Bilkent Şehir Hastanesi

Ankara, Turkey (Türkiye)

Antalya Egitim ve Arastırma Hastanesi

Antalya, Turkey (Türkiye)

Ege Universitesi Hastanesi

Bornova, Turkey (Türkiye)

Dicle Üniversitesi

Diyarbakır, Turkey (Türkiye)

Trakya University

Edirne, Turkey (Türkiye)

Gaziantep Universitesi Sahinbey Arastirma ve Uygulama Hastanesi

Gaziantep, Turkey (Türkiye)

T.C. Sağlik Bakanliği- Marmara Üniversitesi İstanbul Pendik Eğitim Ve Araştirma Hastanesi

Pendik, Turkey (Türkiye)

Sakarya Training and Research Hospital

Sakarya, Turkey (Türkiye)

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NCT07169851

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