IH, Brain Health, and T2D
Intermittent Hypoxia Training and Cerebrovascular Health in Older Adults With Type 2 Diabetes
Darren P Casey
80 participants
Sep 22, 2025
INTERVENTIONAL
Conditions
Summary
The purpose of this study is to use a randomized, placebo-controlled study design to rigorously examine the therapeutic potential of intermittent hypoxia (IH) for improving cerebrovascular health in older adults with and without type 2 diabetes mellitus (T2DM).
Eligibility
Inclusion Criteria8
- For 30 patients with documented Type 2 diabetes
- Willing and able to provide written, signed informed consent after the nature of the study has been explained, and prior to any research-related procedures.
- Age is \> or = 60 and \< or = 85 years of age
- Documented Type 2 diabetes
- Scoring 26 or higher on the MoCA test
- Willing and able to provide written, signed informed consent after the nature of the study has been explained, and prior to any research-related procedures.
- Age is \> or = 60 and \< or = 85 years of age
- Scoring 26 or higher on the MoCA test
Exclusion Criteria22
- diagnosis of type 2 diabetes \< 1 year prior to enrollment
- HbA1c \<6.5% or \>10.0%
- body mass index \> 40 kg/m 2
- incident cardiovascular events in the last year (heart attack, stroke)
- symptomatic coronary artery disease and/or heart failure
- uncontrolled hypertension
- obstructive sleep apnea
- pulmonary disease
- dementia
- renal impairment with creatinine clearance (eGFR) of \<60 ml/min
- smoking or history of smoking within past one year
- nondiabetic control subjects will also be studied.
- Diagnosis of diabetes (Type 1 or Type 2)
- body mass index \> 40 kg/m2
- incident cardiovascular events in the last year (heart attack, stroke)
- symptomatic coronary artery disease and/or heart failure
- uncontrolled hypertension
- obstructive sleep apnea
- pulmonary disease
- dementia
- renal impairment with creatinine clearance (eGFR) of \<60 ml/min
- smoking or history of smoking within past one year
Interventions
Intermittent Hypoxia 1 (IH1): 5 cycles of normoxia (4 minutes)/hypoxia (6 minutes) per session. 3 sessions per week for 8 weeks
Intermittent Hypoxia 1 (IH2): 5 cycles of normoxia (4 minutes)/hypoxia (6 minutes) per session. 3 sessions per week for 4 weeks
Participants will receive normoxia (no hypoxia) over 50 minutes.
Locations(1)
View Full Details on ClinicalTrials.gov
For the most up-to-date information, visit the official listing.
NCT07173543