Early Double Sequential Defibrillation in Out of Hospital Cardiac Arrest
"A Randomized Trial Assessing the Effect of Early Double Sequential Defibrillation With Anterior-posterior and Anterior Lateral Pad Placement and Sequential Defibrillation Compared to Standard Pad Placement and Single Defibrillation in Patients With Out of Hospital Cardiac Arrest With Initial Shockable Rhythm and at Least One Failed Standard Defibrillation"
Gabriel Riva
916 participants
Sep 8, 2025
INTERVENTIONAL
Summary
Some of the patients affected by Out-of-hospital cardiac arrest (OHCA) with ventricular fibrillation (VF)/ventricular tachycardia (VT) do not respond to initial defibrillation. The survival decreases with number of defibrillations required to terminate VF/VT. In 2022, one prospective cluster randomized trial showed increased survival among (OHCA) patients in refractory VF using Double Sequential Defibrillation (DSD). If DSD can increase survival among all patients in VF that dont respond to one defibrillation, i.e. before it has become refractory is not known. The aim of this trial is to assess survival with a double defibrillation strategy initiated as soon as possible among patients with Out of Hospital Cardiac Arrest with initial shockable rhythm and at least one failed standard defibrillation, compared with continued resuscitation using standard defibrillation.
Eligibility
Inclusion Criteria1
- OHCA patients with VT/VF at first rhythm analysis and at least one defibrillation performed in standard (A-L) position
Exclusion Criteria3
- Age < 18 years
- Obvious pregnancy
- Known preexisting Do Not Attempt Resuscitation order
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Interventions
A second defibrillator will be applyed with electrodes placed in the A-P position and defibrillation will be performed with two defibrllators in a sequential manner
Standard defibrillation uning one defibrillator
Locations(14)
View Full Details on ClinicalTrials.gov
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NCT07174986