RecruitingNCT07175077

7T Brain MRI Scan for Micro-brain Metastasis (microBM) Detection for Patients With Small-cell Lung Cancer (SCLC), Who Decline Prophylactic Cranial Irradiation (PCI)

Sponsor

University of Missouri-Columbia

Enrollment

20 participants

Start Date

Nov 1, 2025

Study Type

OBSERVATIONAL

Conditions

Comparison of a 7t MRI to standard of care 1.5t/3t MRI scans to determine if earlier detection of brain metastases are possible on a 7t.

Min Age: 18 Years

Patient must have a histologically confirmed diagnosis of small-cell lung cancer (SCLC). • Patient must have an MRI of the brain, performed within 4 weeks prior to consent, documenting no evidence of brain metastases or leptomeningeal disease.
Patient also must not have a history of brain metastases or leptomeningeal disease.
Patient must refuse PCI and agree to surveillance with brain MRI scans (1.5T/3T).
Patient must be ≥ 18 years of age.
Patient must have ECOG Performance Status of 0-2
Patients must be able to tolerate the 7T MRI

Patient must not have a contraindication to an MRI, such as implanted metal devices or foreign bodies.
Patient must not have a contraindication to gadolinium contrast administration during MR imaging.
Patient must not have other metastatic malignancies requiring current active treatment.
Pregnant patients are excluded. Pregnancy status will be confirmed verbally.

DEVICE7t MRI

7t brain MRI followed by up to 12 months of standard of care 1.5t/3t MRI scans

University of Missouri

Columbia, Missouri, United States

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NCT07175077