Brain Metastases Clinical Trials

127 recruitingLast updated: June 17, 2026

There are 127 actively recruiting brain metastases clinical trials across 37 countries. Studies span Phase 2, Not Applicable, Phase 1, Phase 3, Early Phase 1, Phase 4. Top locations include Houston, Texas, United States, New York, New York, United States, Boston, Massachusetts, United States. Updated daily from ClinicalTrials.gov.


Brain Metastases Trials at a Glance

127 actively recruiting trials for brain metastases are listed on ClinicalTrialsFinder across 6 cities in 37 countries. The largest study group is Phase 2 with 60 trials, with the heaviest enrollment activity in Houston, New York, and Boston. Lead sponsors running brain metastases studies include M.D. Anderson Cancer Center, Fudan University, and Baptist Health South Florida.

Browse brain metastases trials by phase

Treatments under study

About Brain Metastases Clinical Trials

Looking for clinical trials for Brain Metastases? There are currently 86 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Brain Metastases trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Brain Metastases clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 127 trials

Recruiting
Phase 2

UCSD Image-Guided Cognitive-Sparing Radiosurgery for Brain Metastases

CancerBrain Metastases, AdultNeurocognitive Function
Jona Hattangadi-Gluth60 enrolled1 locationNCT04343157
Recruiting
Phase 2

A Study of Stereotactic Radiosurgery (SRS) for People With Lung Cancer That Has Spread to the Brain

Lung CancerBrain Metastases, AdultBrain Metastases+3 more
Memorial Sloan Kettering Cancer Center62 enrolled7 locationsNCT05419076
Recruiting
Phase 3

Stereotactic Radiosurgery Compared With Hippocampal-Avoidant Whole Brain Radiotherapy (HA-WBRT) Plus Memantine for 5 or More Brain Metastases

Brain Metastases
Canadian Cancer Trials Group206 enrolled86 locationsNCT03550391
Recruiting
Phase 1

A Phase 1/1b Study of IAM1363 in HER2 Cancers

HER2-positive Breast CancerHER2 + Breast CancerHER2 Mutation-Related Tumors+10 more
Iambic Therapeutics, Inc383 enrolled53 locationsNCT06253871
Recruiting

Early [18F]-FDG PET Dynamic Analysis in Brain Metastases After Radiotherapy.

Brain MetastasesRadiation NecrosisShort Time Examination
Centre Hospitalier Universitaire, Amiens50 enrolled1 locationNCT07632092
Recruiting
Not Applicable

MeDex: No Perioperative Dexamethasone in Brain Metastases

Brain Metastases
University of Louisville35 enrolled1 locationNCT07044557
Recruiting
Phase 1

Study to Assess Safety, Tolerability and Activity of DSB2455 in Participants With Advanced Malignancies

Advanced Malignancies With Homologous Recombination Deficiency (HRD) (Breast, Ovarian, mCRPC, Brain Metastases)
Duke Street Bio Ltd180 enrolled15 locationsNCT06458712
Recruiting
Phase 2

Avoiding Radiation Therapy Due to Intracranial Response to Chemotherapy, Targeted Therapy and/or Immuno-ONcology Therapy for Brain Metastases: Pilot Pragmatic Trial

Brain Metastases, AdultBrain Metastases From Non-small Cell Lung Cancer (NSCLC)
University of Vermont Medical Center45 enrolled1 locationNCT06974370
Recruiting
Phase 1

18F-Fluciclovine PET Amino Acid Evaluation of Brain Metastasis Treated With Stereotactic Radiosurgery

Brain Metastases, AdultBrain MetastasesBrain Cancer
Baptist Health South Florida46 enrolled1 locationNCT06048094
Recruiting
Phase 2

Trial of Relatlimab, Nivolumab, and Ipilimumab in Patients With Asymptomatic and Symptomatic Melanoma Brain Metastases

MelanomaBrain Metastases
Stanford University60 enrolled1 locationNCT06712927
Recruiting
Phase 1

Stereotactic Radiosurgery Dose Escalation for Brain Metastases

Brain Metastases
University of Utah50 enrolled1 locationNCT02390518
Recruiting
Not Applicable

ioMRI in the Surgery of Brain Metastases.

Brain Metastases
Technical University of Munich154 enrolled1 locationNCT07197632
Recruiting
Phase 2

Efficacy and Safety of SPH4336 in Combination With Endocrine Therapy in Breast Cancer Patients With Brain Metastases.

Breast Cancer Brain Metastases
Shanghai Pharmaceuticals Holding Co., Ltd52 enrolled25 locationsNCT05872347
Recruiting
Not Applicable

Development of MRF for Characterization of Brain Tumors After Radiotherapy

Brain MetastasesBrain TumorGlioma+1 more
Case Comprehensive Cancer Center90 enrolled2 locationsNCT06101069
Recruiting
Not Applicable

Neoadjuvant vs. Intraoperative vs. Adjuvant Resection Cavity Radiotherapy of Brain Metastases

Brain MetastasesRadiotherapy
University Hospital Heidelberg90 enrolled1 locationNCT05871307
Recruiting
Phase 2

Optimizing Neurocognition With Whole Brain Radiation Therapy (WBRT) Using Upfront Pulsed Reduced Dose-Rate (PRDR) Technique

Brain Metastases
Medical College of Wisconsin53 enrolled2 locationsNCT05045950
Recruiting
Not Applicable

Preoperative vs Postoperative Hypofractionated Radiosurgery for Patients With Large Brain Metastases

Brain Metastases, Adult
Istituto Clinico Humanitas146 enrolled9 locationsNCT05545007
Recruiting
Phase 1

Assess Use of 18F-Fluciclovine for Patients With Large Brain Metastases Treated With Staged Stereotactic Radiosurgery

Brain Metastases, AdultBrain MetastasesBrain Cancer
Baptist Health South Florida20 enrolled1 locationNCT04689048
Recruiting
Phase 2

Inflammation in Primary and Secondary Malignancies of the Central Nervous System Using [C-11]-CS1P1

Brain MetastasesCentral Nervous System Cancer
Washington University School of Medicine104 enrolled1 locationNCT07462507
Recruiting
Phase 1Phase 2

Phase 1/2 Trial of S241656 in Selected RAS/MAPK Mutation- Positive Malignancies

Colorectal, CancerColorectal CarcinomaNon-small Cell Lung Cancer+29 more
Institut de Recherches Internationales Servier554 enrolled11 locationsNCT05786924