Advanced Dressings for CVC Infection Prevention in PICU
Use of Advanced Fixation Dressings in Reducing Central Venous Catheter-related Bloodstream Infections in a Paediatric Intensive Care Unit
University of Seville
250 participants
May 1, 2024
INTERVENTIONAL
Conditions
Summary
Randomised, single-blind clinical trial comparing chlorhexidine gluconate-impregnated transparent dressings versus conventional transparent dressings in the prevention of central venous catheter-related bloodstream infections (CVC-BSI) in paediatric patients admitted to a tertiary hospital PICU. Outcomes include incidence of BRCVC, catheter colonisation, dressing-related skin complications, and number of dressing changes.
Eligibility
Inclusion Criteria3
- Admission to paediatric intensive care unit (PICU)
- Central venous catheter placement (central or peripherally inserted)
- Informed consent obtained from parent/legal guardian
Exclusion Criteria3
- Known immunological disorders
- Neutropenia (\<500/mm³)
- Pre-existing colonisation or infection with multidrug-resistant organisms
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Interventions
Individually applied transparent dressing containing chlorhexidine gluconate (0.5-1 mg/cm²) for antimicrobial protection at the central venous catheter insertion site. The dressing maintains site visibility, reduces catheter manipulation frequency, and provides sustained release of chlorhexidine to lower colonisation and bloodstream infection risk.
Transparent polyurethane dressing without antimicrobial impregnation, applied at the central venous catheter insertion site. This dressing allows site inspection and is widely used in standard paediatric intensive care protocols but provides no antimicrobial activity.
Locations(1)
View Full Details on ClinicalTrials.gov
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NCT07175116