RecruitingPhase 2NCT07175220

Phase II Clinical Study of SHR2554 Tablets Combined With Other Anti-tumor Treatments in Non-small Cell Lung Cancer Subjects

A Multicenter, Open Label Phase II Clinical Study on the Safety, Tolerability, and Efficacy of SHR2554 Tablets in Combination With Other Anti-tumor Treatments in Subjects With Locally Advanced or Metastatic Non-small Cell Lung Cancer


Sponsor

Jiangsu HengRui Medicine Co., Ltd.

Enrollment

200 participants

Start Date

Oct 9, 2025

Study Type

INTERVENTIONAL

Conditions

Summary

Evaluate the safety, tolerability, and objective response rate (ORR) of SHR2554 tablets in combination with other anti-tumor treatments in subjects with locally advanced or metastatic non-small cell lung cancer


Eligibility

Min Age: 18 YearsMax Age: 75 Years

Plain Language Summary

Simplified for easier understanding

This Phase 2 study is testing a drug called SHR2554 combined with other anti-cancer treatments in people with advanced non-small cell lung cancer (NSCLC). SHR2554 works by targeting a protein called EZH2, which can drive cancer cell growth. **You may be eligible if...** - You are between 18 and 75 years old - You have been diagnosed with locally advanced unresectable or metastatic non-small cell lung cancer - Your overall health is good (ECOG score of 0 or 1) - Your expected survival is at least 12 weeks - Your organ function (liver, kidneys, blood) meets study requirements - You are willing to participate and have signed the informed consent form **You may NOT be eligible if...** - You have difficulty swallowing or a gastrointestinal condition that would prevent absorbing the oral medication - You have had a gastrectomy (stomach removal) or gastric banding surgery - You have other serious health conditions that could interfere with treatment Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGSHR2554; SHR-A2102

SHR2554 tablets combined with SHR-A2102 for injection, with a cycle of 21 days

DRUGSHR2554; Adabelimumab

SHR2554 tablets combined with Adabelimumab, with a cycle of 21 days

DRUGSHR2554; SHR-1701

SHR2554 tablets combined with SHR-1701 injection, with a cycle of 21 days


Locations(1)

Sun Yat-sen University Cancer Center

Guangzhou, Guangdong, China

View Full Details on ClinicalTrials.gov

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NCT07175220


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