RecruitingPhase 4NCT07176689

Nirogacestat in Premenopausal Females With Desmoid Tumor/Aggressive Fibromatosis (DT/AF)

A Single-Arm, Open-Label Phase 4 Study of Nirogacestat in Adult Premenopausal Females With Desmoid Tumors/Aggressive Fibromatosis (DT/AF)

Sponsor

SpringWorks Therapeutics, Inc., a healthcare company of Merck KGaA, Darmstadt, Germany

Enrollment

50 participants

Start Date

Sep 17, 2025

Study Type

INTERVENTIONAL

Conditions

Desmoid Tumor Aggressive Fibromatosis

Summary

This study is being conducted to study how nirogacestat may affect the ovarian function of adult premenopausal women with progressing desmoid tumors/aggressive fibromatosis.

Eligibility

Sex: FEMALEMin Age: 18 YearsMax Age: 40 Years

Plain Language Summary

Simplified for easier understanding

This clinical trial is studying a drug called Nirogacestat for people with aggressive fibromatosis and desmoid tumor. The study is currently recruiting participants at 23 locations. People eligible for this study include women aged 18 Years to 40 Years.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

Interested in this trial?

Get notified about updates and connect with the research team.

Interventions

DRUGNirogacestat

Nirogacestat oral tablet

Locations(23)

Cliniques Universitaires Saint-Luc (CUSL)

Brussels, Belgium

Universitaetsmedizin Mannheim

Mannheim, Germany

IRCCS Istituto Romagnolo per lo Studio dei Tumori "Dino Amadori" - IRST S.r.l.

Meldola, Forli-Cesena, Italy

La Fondazione e l'Istituto di Candiolo

Candiolo, Torino, Italy

IRCCS Azienda Ospedaliero-Universitaria di Bologna - Policlinico di Sant Orsola

Bologna, Italy

IRCCS Istituto Ortopedico Rizzoli di Bologna

Bologna, Italy

Fondazione IRCCS Istituto Nazionale dei Tumori Milano

Milan, Italy

Istituto Nazionale Tumori I.R.C.C.S- Fondazione G. Pascale

Naples, Italy

Policlinico Universitario Campus Bio-Medico

Roma, Italy

Nederlands Kanker Instituut - Antoni van Leeuwenhoek Ziekenhuis (NKI-AVL)

Amsterdam, Netherlands

Academisch Ziekenhuis Leiden

Leiden, Netherlands

Hospital de la Santa Creu i Sant Pau

Barcelona, Spain

Institut Catala d'Oncologia

Barcelona, Spain

Hospital General Universitario Gregorio Maranon

Madrid, Spain

Hospital Fundacion Jimenez Diaz

Madrid, Spain

Hospital Universitario 12 de Octubre

Madrid, Spain

Hospital Universitario La Paz

Madrid, Spain

Hospital Universitari i Politecnic La Fe de Valencia

Valencia, Spain

Hospital Universitario Miguel Servet

Zaragoza, Spain

Cambridge University - Addenbrooke's Hospital

Cambridge, United Kingdom

University College London Hospital

London, United Kingdom

The Royal Marsden NHS Foundation Trust

London, United Kingdom

The Christie NHS Foundation Trust

Manchester, United Kingdom

View Full Details on ClinicalTrials.gov

For the most up-to-date information, visit the official listing.

Visit

NCT07176689

Related Trials

A Study in Adults With Desmoid Tumors

NCT075414301 location

A Study of Nirogacestat in Japanese Adults With Desmoid Tumors/Aggressive Fibromatosis (DT/AF)

NCT071706443 locations

Cryoablation Versus Medical Therapy in Desmoid Tumors Progressing After Watchful Waiting

NCT0608140013 locations

Study of Cryoablation and Nirogacestat for Desmoid Tumor

NCT059490991 location