Robotic-Enabled Microsurgical Intervention for Neurodegenerative Disease

This study is testing whether robotic-assisted microsurgery to improve lymphatic drainage from the brain can slow the progression of Alzheimer's disease in people with mild to moderate symptoms. The idea is based on emerging research suggesting that clearing waste from the brain via the lymphatic system may protect brain health. **You may be eligible if...** - You are 50 years or older - You have been diagnosed with mild to moderate Alzheimer's disease per established criteria (NIA-AA) - You have a positive amyloid PET scan or positive cerebrospinal fluid markers confirming Alzheimer's biology - Your memory and thinking tests (MMSE score 10-26, CDR-SB score 4.5-15.5) are within the mild to moderate range - You have confirmed lymphatic drainage abnormalities in the head and neck area on imaging **You may NOT be eligible if...** - Your Alzheimer's disease is severe - You do not have confirmed amyloid pathology on testing - You do not have the specific lymphatic abnormalities targeted by the surgery Talk to your doctor to see if this trial is right for you.