RecruitingPhase 2NCT06467539

Novel Augmentation of DAOIB and Antioxidant for Early Dementia


Sponsor

Chang Gung Memorial Hospital

Enrollment

80 participants

Start Date

Jun 19, 2024

Study Type

INTERVENTIONAL

Conditions

Summary

Previous studies found that some NMDA-enhancing agents were able to improve cognitive function of patients with early-phase dementia. In addition, several drugs with antioxidant properties have been tested in clinical trials for the treatment of dementia too. Whether combined treatment of an NMDA-enhancing agent and a drug with antioxidant property can be better than an NMDA-enhancing agent alone deserves study.


Eligibility

Min Age: 50 YearsMax Age: 90 Years

Plain Language Summary

Simplified for easier understanding

This study is testing a combination of two supplements — DAOIB (a compound that supports brain receptor function) and an antioxidant — to slow cognitive decline in people with early-stage Alzheimer's disease or mild cognitive impairment. **You may be eligible if...** - You have been diagnosed with Alzheimer's disease or mild cognitive impairment - Your cognitive test score (MMSE) is between 10 and 26 - Your clinical dementia rating (CDR) is 0.5 (mild) or 1 (moderate) **You may NOT be eligible if...** - Your vascular risk score (Hachinski score) is above 4, suggesting vascular dementia - You have Parkinson's disease, epilepsy, or dementia with psychotic features - You have a major depressive disorder or serious physical illness - You have severe vision or hearing impairment Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGDAOIB plus AO

oral, for 24 weeks

DRUGDAOIB plus placebo

oral, for 24 weeks


Locations(1)

Chang Gung Memorial Hospital

Kaohsiung City, Taiwan

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NCT06467539


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