RecruitingPhase 2NCT07178808

PHASE II EVALUATION OF CYTOREDUCTION SURGERY AND HYPERTHERMIC INTRAPERITONEAL CHEMOTHERAPY (CRS/HIPEC) IN GASTRIC CANCER


Sponsor

Banner Health

Enrollment

30 participants

Start Date

Apr 16, 2021

Study Type

INTERVENTIONAL

Conditions

Summary

This is a Phase II treatment study analyzing the role of preoperative chemotherapy, preoperative laparoscopic HIPEC, and gastrectomy with CRS/HIPEC in gastric adenocarcinoma patients with cytology-positive only carcinomatosis, radiologically-occult carcinomatosis, or radiology apparent peritoneal-surface only metastatic disease.


Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This Phase 2 study is evaluating a combined surgical and heated chemotherapy treatment — called CRS/HIPEC (cytoreduction surgery followed by hyperthermic intraperitoneal chemotherapy) — for people with stomach cancer that has spread to the lining of the abdomen (peritoneal metastases). **You may be eligible if...** - You are 18 years or older - You have a confirmed diagnosis of adenocarcinoma of the stomach or gastroesophageal junction - Your cancer has spread to the peritoneum (abdominal lining) but may be amenable to surgical removal - Your overall health is adequate for major surgery (ECOG performance status 0-2) - Your blood counts and kidney function meet the study thresholds **You may NOT be eligible if...** - Your cancer has spread beyond the peritoneum to other distant organs (e.g., liver, lungs) - Your overall health or organ function does not support major surgery - Your cancer is too widespread in the abdomen to allow complete surgical removal Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

PROCEDURECytoreductive surgery and hyperthermic intraperitoneal chemotherapy

CRS/HIPEC involves aggressive surgical cytoreduction of all visible and palpable tumors, followed by the synergistic use of heated and high dose chemotherapy to address microscopic residual disease.


Locations(1)

Banner MD Anderson Cancer Center

Gilbert, Arizona, United States

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NCT07178808


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