RecruitingNot ApplicableNCT07179159

Efficacy and Safety of 14-Day Vonoprazan-Based Dual Therapy Versus Quadruple Therapy for Helicobacter Pylori Eradication: A Multicentre, Non-Inferiority Randomized Controlled Trial

Sponsor

Yanqing Li

Enrollment

372 participants

Start Date

Sep 9, 2025

Study Type

INTERVENTIONAL

Conditions

Helicobacter Pylori Infections

Summary

This study is a multicentre, non-inferiority randomized controlled trial to compare the efficacy and safety of 14-day vonoprazan-based dual therapy with versus quadruple therapy for the eradication of Helicobacter pylori. The primary outcome is eradication rate, and the secondary outcome includes the incidence of adverse events and compliance.

Eligibility

Min Age: 18 YearsMax Age: 70 Years

Plain Language Summary

Simplified for easier understanding

This clinical trial is studying a drug called 14-day vonoprazan-amoxicillin dual therapy, a drug called 14-day vonoprazan-amoxicillin-clarithromycin-bismuth quadruple therapy, and others for people with helicobacter pylori infections. The study is currently recruiting participants at 2 locations. People eligible for this study include aged 18 Years to 70 Years.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUG14-day vonoprazan-amoxicillin dual therapy

vonoprazan 20mg bid + amoxicillin 1000mg bid

DRUG14-day vonoprazan-amoxicillin-levofloxacin-bismuth quadruple therapy

vonoprazan 20mg bid + amoxicillin 1000mg bid + levofloxacin 500mg qd + bismuth 220mg bid

DRUG14-day vonoprazan-amoxicillin-clarithromycin-bismuth quadruple therapy

vonoprazan 20mg bid + amoxicillin 1000mg bid + clarithromycin 500mg bid + bismuth 220mg bid

Locations(2)

Qilu Hospital of Shandong University

Jinan, Shandong, China

Qilu Hospital of Shandong University

Jinan, China

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NCT07179159

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