Focused Ultrasound Blood-Brain Barrier Disruption for the Treatment of High-Grade Glioma in Patients Undergoing Standard Chemotherapy

This study is testing whether using focused ultrasound to temporarily open the blood-brain barrier — the protective shield around the brain — can improve the delivery of chemotherapy to glioblastoma tumors. Standard chemotherapy often cannot cross this barrier effectively, limiting its ability to treat brain tumors. **You may be eligible if...** - You are between 18 and 85 years old - You have been diagnosed with glioblastoma (a type of brain cancer) confirmed by tissue analysis using WHO 2021 criteria - You have already completed the initial surgery plus concurrent radiation and temozolomide chemotherapy without complications - You are eligible to begin the maintenance phase of temozolomide chemotherapy - Your Karnofsky Performance Score is 70-100 (able to care for yourself and carry on normal activities) **You may NOT be eligible if...** - You have not yet completed the initial chemoradiotherapy phase - Your Karnofsky score is below 70 - You have conditions that make focused ultrasound or anesthesia unsafe (e.g., ASA score above the threshold) Talk to your doctor to see if this trial is right for you.