RecruitingPhase 1NCT07179679

A Clinical Study Assessing the Subcutaneous Formulation of TQB2934 for Injection in Subjects With Malignant Plasma Cell Tumors

A Phase I Clinical Study to Evaluate the Safety and Pharmacokinetics of TQB2934 Subcutaneous Preparation for Injection in Subjects With Malignant Plasma Cell Tumors


Sponsor

Chia Tai Tianqing Pharmaceutical Group Nanjing Shunxin Pharmaceutical Co., Ltd.

Enrollment

42 participants

Start Date

Dec 9, 2025

Study Type

INTERVENTIONAL

Conditions

Summary

TQB2934 is an anti-Cluster of Differentiation 3 (CD3) (Early T Cell Marker)×B cell maturation antigen (BCMA) double-specific antibody,and the isoform is IgG1(Native Immunoglobulin G1), which at one end binds to the CD3 receptor on the surface of T cells ,and the other end binds to BCMA(B cell maturation antigen) to recruit T cells around BCMA-positive cells, which can activate T cells .Active T cells release granzyme and perforin to kill BCMA-positive target cells. TQB2934 for injection (subcutaneous injection) is intended for the treatment of patients with multiple myeloma.


Eligibility

Min Age: 18 YearsMax Age: 75 Years

Plain Language Summary

Simplified for easier understanding

This study is testing a new injectable treatment called TQB2934 given under the skin for people with multiple myeloma (a cancer of plasma cells in the bone marrow) that has come back or stopped responding to previous treatments. **You may be eligible if...** - You are between 18 and 75 years old - You have been diagnosed with multiple myeloma that has relapsed or is no longer responding to treatment - You have already tried at least one prior treatment including a proteasome inhibitor, an immunomodulator, and a CD38 antibody (such as daratumumab) - Your cancer has measurable signs of disease - You are in reasonably good general health **You may NOT be eligible if...** - You have received a bone marrow transplant from a donor within the past year, or your own stem cells within the past 3 months - You have received previous CD3×BCMA bispecific antibody therapy - You have active, uncontrolled infections, liver disease, or serious heart or lung conditions - You are pregnant, planning to become pregnant, or breastfeeding - You have had another cancer within the past 3 years Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGTQB2934 injection (subcutaneous injection)

TQB2934 is an anti-CD3(Early T Cell Marker)×BCMA (B cell maturation antigen)double-specific antibody,and the isoform is Native Immunoglobulin G1 ( IgG1), which at one end binds to the CD3 receptor on the surface of T cells ,and the other end binds to BCMA(B cell maturation antigen) to recruit T cells around BCMA-positive cells, which can activate T cells .Active T cells release granzyme and perforin to kill BCMA-positive target cells.


Locations(14)

Chongqing University Cancer Hospital

Chongqing, Chongqing Municipality, China

Nanfang Hospital, Southern Medical University

Guangzhou, Guangdong, China

Guangdong Provincial People's Hospital

Guangzhou, Guangdong, China

The Affiliated Hospital of Chengde Medical College

Chengde, Hebei, China

North China University of Science and Technology Affiliated Hospital

Tangshan, Hebei, China

Nanjing Drum Tower hospital

Nanjing, Jiangsu, China

Jiangsu Province Hospital

Nanjing, Jiangsu, China

The Second Affiliated Hospital of Soochow University

Suzhou, Jiangsu, China

Nanchang University First Affiliated Hospital

Nanchang, Jiangxi, China

The First Affiliated Hospital of Xi'an Jiaotong University

Xi'an, Shaanxi, China

Heze Municipal Hospital

Heze, Shandong, China

Zhongshan Hospital of Fudan University

Shanghai, Shanghai Municipality, China

Affiliated Hospital of North Sichuan Medical College

Nanchong, Sichuan, China

Tianjin People's Hospital

Tianjin, Tianjin Municipality, China

View Full Details on ClinicalTrials.gov

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NCT07179679


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