Neoadjuvant High Dose Rate Brachytherapy Prior to Radical Prostatectomy in Patients With Prostate Cancer

This study is testing whether giving high-dose rate brachytherapy (internal radiation delivered directly to the prostate using small seeds) before surgical prostate removal can improve outcomes in men with high-risk prostate cancer. It combines two treatment approaches that are each effective alone. **You may be eligible if...** - You are 40 or older - You have been diagnosed with prostate cancer confirmed by biopsy - Your cancer is considered high-risk based on PSA levels, Gleason score (a measure of cancer aggressiveness), or the size/stage of the tumor - Your cancer has not spread to bones or lymph nodes (confirmed by scan) - You are in good enough health to undergo both the radiation and surgery procedures **You may NOT be eligible if...** - Your cancer has spread beyond the prostate to lymph nodes or other organs - You have previously received hormone therapy, radiation, or surgery for prostate cancer - You are not medically fit for surgery Talk to your doctor to see if this trial is right for you.