Metabolic Effects of Short-Chain Fatty Acids in Healthy Individuals
University of Copenhagen
10 participants
Sep 10, 2025
INTERVENTIONAL
Conditions
Summary
The primary objective of this study is to investigate the acute physiological and metabolic effects of ingesting the short-chain fatty acids (SCFA)s propionate (three carbon atoms long; C3:0) and butyrate (C4:0) in healthy men and women. This aim will be addressed through a block-randomized cross-over study including two visits with acute intake of propionate and butyrate, respectively. The hypothesis is that plasma ketone body levels will increase during the first three hours after intake of butyrate, but not propionate, in healthy individuals in the overnight fasted state.
Eligibility
Inclusion Criteria3
- Male or female.
- Age between 18-40 years old
- BMI between 18.5-29
Exclusion Criteria10
- Diabetes
- Kidney- or liver disease
- Pregnant, lactating or planning to become pregnant within the study period
- Supplementation with SCFAs
- Supplementation with B12 vitamin
- Special dietary habits (e.g. vegan/ketogenic diet)
- Ongoing cancer treatment
- Metabolic or absorptive disorders, gastric bypass operation, or use of medication affecting metabolism or food absorption
- Crohn's disease, ulcerative colitis or short bowel syndrome
- Inability, physically or mentally, to comply with the procedure required by the study protocol as evaluated by the primary investigator, study manager or clinical responsible
Interested in this trial?
Get notified about updates and connect with the research team.
Interventions
The participants will consume Short-chain fatty acid propionate (SCFA-PRO) followed by Short-Chain Fatty Acid Butyrate (SCFA-BUT).
• The participants will consume Short-chain fatty acid Butyrate (SCFA-BUT) followed by Short-Chain Fatty Acid Propionate (SCFA-PRO).
• The participants will consume Short-Chain Fatty Acid propionate (SCFA-PRO) followed by Short-Chain Fatty Acid Butyrate (SCFA-BUT).
The participants will consume Short-Chain Fatty Acid Butyrate (SCFA-BUT) followed by Short-Chain Fatty Acid Propionate (SCFA-PRO).
Locations(1)
View Full Details on ClinicalTrials.gov
For the most up-to-date information, visit the official listing.
NCT07183488