Effects of Mindfulness or Brain Stimulation Intervention for Late-life Adults in Taiwan Urban and Rural Areas
Intervention Evaluation for Late-life Depression in Taiwan Urban and Rural Areas: Long-term Tracking and Prediction of Non-pharmaceutical Interventions by Smart AI Technologies
National Health Research Institutes, Taiwan
124 participants
Aug 1, 2025
INTERVENTIONAL
Conditions
Summary
This randomized controlled trial will examine the effects of mindfulness-based interventions and brain stimulation interventions on cognitive function and psychological well-being in older adults. The study will employ a comprehensive assessment approach incorporating psychological evaluations, behavioral assessments, psychophysiological measurements, and neuroimaging analyses to characterize the outcome of nonpharmaceutical interventions in improving geriatric well-being or reducing depression severity.
Eligibility
Inclusion Criteria8
- Literate or have received an education above the elementary level.
- Have normal or corrected vision and hearing, able to communicate and understand explanations.
- Right-handed individuals as assessed by the Edinburgh Handedness Inventory.
- Individuals diagnosed with major depressive disorder by psychiatrists according to the Diagnostic and Statistical Manual, and who can cooperate with the psychiatric outpatient clinic regulations.
- Literate or have received an education above the elementary level.
- Have normal or corrected vision and hearing, able to communicate and understand explanations.
- Right-handed individuals as assessed by the Edinburgh Handedness Inventory.
- Individuals are prescribed brain stimulation therapy by clinical physicians.
Exclusion Criteria14
- Individuals with dementia, stroke, cerebrovascular disease, brain injury, epilepsy, or Parkinson's disease.
- Individuals with neurological system disorders.
- Individuals with alcohol or drug dependence.
- Individuals with other major physical illnesses, such as diabetes, heart failure, or endocrine abnormalities, or those who have experienced an acute myocardial infarction within the past three months.
- Individuals with metal objects in the body that cannot undergo magnetic resonance imaging (MRI), such as cardiac pacemakers, vascular clips, hearing aids, artificial joints, steel pins, etc.
- Individuals with Claustrophobia.
- Individuals in pregnancy or possibility of pregnancy.
- Individuals with dementia, stroke, cerebrovascular disease, brain injury, epilepsy, or Parkinson's disease.
- Individuals with neurological system disorders.
- Individuals with alcohol or drug dependence.
- Individuals with other major physical illnesses, such as diabetes, heart failure, or endocrine abnormalities, or those who have experienced an acute myocardial infarction within the past three months.
- Individuals with metal objects in the body that cannot undergo magnetic resonance imaging (MRI), such as cardiac pacemakers, vascular clips, hearing aids, artificial joints, steel pins, etc.
- Individuals with Claustrophobia.
- Individuals in pregnancy or possibility of pregnancy.
Interventions
Mindfulness-Based Stress Reduction
Mindfulness-Based Well-Being Curriculum
Mindfulness-Based Curriculum for Insomnia
Brain Stimulation Intervention
Locations(2)
View Full Details on ClinicalTrials.gov
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NCT07186023