RecruitingNCT07186127

Methotrexate Treatment in Cases of Ectopic Pregnancy With Relative Contraindications

A Retrospective Evaluation of the Effectiveness of Methotrexate Treatment in Cases of Ectopic Pregnancy With Relative Contraindications


Sponsor

Bagcilar Training and Research Hospital

Enrollment

230 participants

Start Date

May 1, 2025

Study Type

OBSERVATIONAL

Conditions

Summary

Study Description (For Patients, Families, and Healthcare Providers) Purpose: The aim of this study is to evaluate the effectiveness and safety of methotrexate treatment in women with ectopic pregnancy who belong to a group for whom this treatment is relatively contraindicated. Background: Methotrexate is a medication commonly used in the treatment of ectopic pregnancy (a pregnancy that occurs outside the uterus, usually in the fallopian tube). However, in certain conditions - such as kidney or liver dysfunction - methotrexate use may carry increased risks. These situations are known as relative contraindications. This study will retrospectively examine treatment outcomes in this specific patient population. Method: The study will analyze medical records of patients who were previously treated with methotrexate for ectopic pregnancy. No new interventions will be performed. The analysis will be based solely on existing clinical data. Why Is This Important? The findings of this study may help us better understand the safety limits of methotrexate therapy and guide healthcare providers in managing similar cases in the future.


Eligibility

Sex: FEMALEMin Age: 18 YearsMax Age: 48 Years

Inclusion Criteria4

  • Diagnosed with ectopic pregnancy
  • Received methotrexate (MTX) treatment
  • Underwent surgical treatment due to lack of response to MTX therapy
  • Compliant with treatment follow-up

Exclusion Criteria2

  • Participants with contraindications to methotrexate (MTX) treatment
  • Participants non-compliant with follow-up

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Interventions

DRUGDrug: Methotrexate (MTX) Patients received methotrexate treatment according to institutional protocols. Dosage and administration routes were recorded retrospectively. For patients who did not respond

MTX medical treatment Laparoscopic salpingectomy Laparoscopic salpingostomy


Locations(1)

University of Health Sciences, Training and Research Hospital

Istanbul, Türkiye, Turkey (Türkiye)

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NCT07186127


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