Mitigating the Disinhibiting Effects of Alcohol With Transcranial Magnetic Stimulation
Michael J. Wesley, PhD
12 participants
Oct 30, 2025
INTERVENTIONAL
Conditions
Summary
The goal of this clinical trial is to learn how a specific type of brain stimulation affects alcohol-related decision-making and self-control in adults who drink alcohol. The main questions the study aims to answer are: * Does brain stimulation change how people behave after drinking alcohol? * Does the combination of alcohol and different types of brain stimulation affect people's ability to make thoughtful decisions or resist impulses? Researchers will compare the effects of two types of brain stimulation, intermittent theta burst stimulation (iTBS) and continuous theta burst stimulation (cTBS), after people drink alcohol or a placebo drink. A sham (placebo) stimulation condition will also be included. The study uses a within-person design, which means each participant will take part in all conditions. Participants will: * Attend five separate study visits * Drink either an alcoholic or placebo beverage * Receive one of the brain stimulation conditions (real or sham) * Complete decision-making tasks before and after drinking The tasks will measure things like impulsive choices and reaction time. The researchers hope this study will help identify how brain stimulation could be used to improve decision-making during intoxication, which might one day reduce harmful drinking behaviors or prevent alcohol-related accidents.
Eligibility
Inclusion Criteria7
- Age 21-29
- Must be competent in English
- BMI between 19 and 26
- At least a high school education
- Moderate alcohol users (e.g., at least occasional alcohol use, without meeting criteria for alcohol use disorder)
- Negative urine drug screen for illicit drugs
- Negative urine pregnancy test (if applicable) on testing days
Exclusion Criteria8
- History of seizures or a first-degree relative with seizure history
- History of head trauma or other CNS injuries
- Current or past psychiatric disorders (including substance use disorder, except nicotine or caffeine)
- Contraindications for non-invasive brain stimulation (e.g., metal implants, pacemaker)
- Currently pregnant or breastfeeding
- Current use of medications that lower seizure threshold
- Positive alcohol withdrawal symptoms
- Smokes more than five cigarettes per day (to avoid acute nicotine effects or withdrawal during visits)
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Interventions
Intermittent Theta Burst Stimulation (iTBS) is then delivered to the left DLPFC using a MagVenture TMS device. Each iTBS session includes 600 pulses delivered in 3-pulse bursts at 50 Hz, every 200 ms (5 Hz), in 2 sec on / 8 sec off cycles at 110% resting motor threshold (RMT). Stimulation is ramp-up from 80% to 110% RMT (\~90 pulses). Two iTBS sessions are given per visit, separated by 30 minutes. The second session is timed to correspond to the peak BAC.
Continuous Theta Burst Stimulation (cTBS) is then delivered to the left DLPFC using a MagVenture TMS device. Each cTBS session includes 2 bouts of 1800 pulses separated by a 1 minute rest period. Each bout is delivered in 3-pulse bursts at 50 Hz, every 200 ms (5 Hz), continuously for \~120 seconds at 110% resting motor threshold (RMT). Stimulation is ramped up from 80% to 110% RMT over the first 30 seconds. Two cTBS sessions are given per visit, separated by 30 minutes. The second session is timed to correspond to the peak BAC.
Sham Transcranial Magnetic Stimulation (TMS) is delivered to the left DLPFC using the sham side of a MagVenture TMS coil, paired with synchronized scalp electrodes to mimic the sensation of real TMS. The sham procedure matches the timing and auditory cues of either iTBS or cTBS protocols, depending on random assignment. Two sham stimulation sessions are given per visit, separated by 30 minutes. The second session is timed to correspond to the peak BAC.
Locations(1)
View Full Details on ClinicalTrials.gov
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NCT07188376