Metastatic Ewing's Trial Testing Schedule Enhancement to Improve Outcomes
H. Lee Moffitt Cancer Center and Research Institute
15 participants
Feb 5, 2026
INTERVENTIONAL
Conditions
Summary
This single arm study is designed to demonstrate the feasibility of a radically different approach for an exceptionally high-risk subset of MES with widely metastatic disease (WMES). We incorporate the use of evolutionary principles that apply to species and population dynamics as related to adaptation and extinction to populations of cancer cells that similarly adapt and that we are attempting to make extinct, resulting in a cure for the patient. Such principles include an initial intense first strike to deplete the bulk of the cancer cells, followed by a series of sequential second strikes towards eliminating residual, resistant populations, followed by a prolonged period of maintenance chemotherapy to eliminate any remnant cells, using agents generally regarded to be active against newly diagnosed ES.
Eligibility
Plain Language Summary
Simplified for easier understanding
This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.
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Interventions
IV Push
IV
IV and Maintenance PO
IV
IV
IV
PO
IV
IV
PO
IV
Locations(17)
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NCT07194044