RecruitingNot ApplicableNCT07194174

Effect of Physical Training in Individuals With Hypokalemic and Hyperkalemic Periodic Paralysis


Sponsor

Rigshospitalet, Denmark

Enrollment

36 participants

Start Date

Oct 2, 2025

Study Type

INTERVENTIONAL

Conditions

Summary

This study wishes to investigate the effects of strength exercise in patients with either HypoPP or HyperPP. The investigators wishes to include participants already diagnosed with either HypoPP or HyperPP in af 24 week prospective study where the patients will be tested and asked to fill out questionnaires three times. These appointments will be schedueled at week 0, week 12 and week 24. In the time period between week 12 and week 24, the patients will have a personalized strength exercise program, which they will have to follow these 3 months. The exercise will be supervised by one or more of the investigators. We will also assess the muscle structure and function cross sectionally.


Eligibility

Min Age: 18 Years

Inclusion Criteria3

  • Patients with genetic verified HypoPP or HyperPP
  • Age minimum 18 years
  • Able to walk a minimum of 10 meters independently with or without assistive devices and be able to stand from a chair without using hands

Exclusion Criteria9

  • Other significant cause of muscle weakness
  • Heart or lung disease which, in the investigator's opinion, makes participation in the study training inadvisable
  • Exclusion from muscle biopsy
  • Anticoagulant treatment
  • Impaired blood clotting due to disease
  • Exclusion from MRI scanning due to:
  • Metal implants in the body that contraindicate MRI scanning or are positioned such that the scan quality is significantly affected
  • Claustrophobia
  • Pregnancy

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Interventions

OTHERStrength exercise

3 weekly supervised trainings with specific strengt exercises


Locations(1)

Rigshospitalet, Copenhagen Neuromuscular Center

Copenhagen, Denmark

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NCT07194174