Effect of Physical Training in Individuals With Hypokalemic and Hyperkalemic Periodic Paralysis
Rigshospitalet, Denmark
36 participants
Oct 2, 2025
INTERVENTIONAL
Conditions
Summary
This study wishes to investigate the effects of strength exercise in patients with either HypoPP or HyperPP. The investigators wishes to include participants already diagnosed with either HypoPP or HyperPP in af 24 week prospective study where the patients will be tested and asked to fill out questionnaires three times. These appointments will be schedueled at week 0, week 12 and week 24. In the time period between week 12 and week 24, the patients will have a personalized strength exercise program, which they will have to follow these 3 months. The exercise will be supervised by one or more of the investigators. We will also assess the muscle structure and function cross sectionally.
Eligibility
Inclusion Criteria3
- Patients with genetic verified HypoPP or HyperPP
- Age minimum 18 years
- Able to walk a minimum of 10 meters independently with or without assistive devices and be able to stand from a chair without using hands
Exclusion Criteria9
- Other significant cause of muscle weakness
- Heart or lung disease which, in the investigator's opinion, makes participation in the study training inadvisable
- Exclusion from muscle biopsy
- Anticoagulant treatment
- Impaired blood clotting due to disease
- Exclusion from MRI scanning due to:
- Metal implants in the body that contraindicate MRI scanning or are positioned such that the scan quality is significantly affected
- Claustrophobia
- Pregnancy
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Interventions
3 weekly supervised trainings with specific strengt exercises
Locations(1)
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NCT07194174