Exercise Therapy for Isotretinoin Users
Prophylactic Exercise Therapy for Musculoskeletal Side Effects in Isotretinoin Users: A Controlled Study
Uşak University
160 participants
Sep 30, 2025
INTERVENTIONAL
Conditions
Summary
Isotretinoin (13-cis retinoic acid) is a retinoic acid that is a derivative of vitamin A. Isotretinoin has been used effectively alone in acne treatment for 35 years. However, it has many side effects. Among the musculoskeletal side effects of this treatment, acute sacroileitis is a common condition. In this clinical picture, recovery may last for a few months after discontinuation of isotretinoin treatment. However, it may become permanent in some cases. According to our current knowledge, there is no study in the literature that prescribes exercise therapy for this patient group. This study, planned to investigate the effects of stretching and sacroiliac mobilization exercises on musculoskeletal pain and quality of life, which are among the side effects of isotretinoin treatment.
Eligibility
Inclusion Criteria3
- The participant is between the ages of 18-35,
- Not having a regular exercise habit,
- Starting Isotretinoin treatment for the first time.
Exclusion Criteria4
- Presence of any diagnosed rheumatologic disease,
- The presence of any diagnosed neurological disease,
- Having any diagnosed psychiatric illness,
- Having a physical disability that prevents them from exercising for any reason.
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Interventions
The 18-Week Program Structure This program is divided into three 6-week phases. Each week consists of 5 sessions, mixing different focuses to ensure balanced development. Day 1: Foundational Strength \& Stability Day 2: Low-Impact Cardio \& Active Recovery Day 3: Core Focus \& Hip Stability Day 4: Low-Impact Cardio \& Mobility Day 5: Full Body Integration \& Strength
Locations(1)
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NCT07196787