RecruitingPhase 1NCT07198867

A Study of A-CAR028 Treatment in Subjects With Relapsed or Refractory Acute Myeloid Leukemia

A Study of A-CAR028 Treatment in Subjects With Relapsed/ Refractory Acute Myeloid Leukemia


Sponsor

First Affiliated Hospital of Zhejiang University

Enrollment

20 participants

Start Date

Sep 30, 2025

Study Type

INTERVENTIONAL

Conditions

Summary

This is a single-center, open-label study to evaluate the safety and efficacy of A-CAR028 in relapsed/refractory acute myeloid leukemia patients


Eligibility

Min Age: 18 YearsMax Age: 75 Years

Plain Language Summary

Simplified for easier understanding

This study is testing a new CAR-T cell therapy called A-CAR028 for people with relapsed or treatment-resistant acute myeloid leukemia (AML) — a fast-growing blood cancer. CAR-T therapy involves engineering a patient's own immune cells to attack the cancer. **You may be eligible if...** - You are 18–75 years old - You have AML that has come back or stopped responding to treatment - Your ECOG performance status is 0 or 1 (able to carry out normal activities) - Your major organ functions are within acceptable range - Your expected survival is more than 12 weeks **You may NOT be eligible if...** - You have a specific subtype called acute promyelocytic leukemia (APL) or mixed phenotype acute leukemia - You have only disease outside the bone marrow (extramedullary only) - You have had a stem cell transplant within the past 3 months - You have had a heart attack, serious heart disease, or a pacemaker in the past year Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

BIOLOGICALA-CAR028

A-CAR028 is a novel 2nd generation 4-1BB bispecific chimeric antigen receptor T-cell (CAR-T) targeting both CD33 and CLL-1 antigens


Locations(1)

Department of Hematology, The First Affiliated Hospital, School of Medicine, Zhejiang University

Hangzhou, Zhejiang, China

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NCT07198867


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