RecruitingPhase 2NCT07199764

Maintenance Combinatorial Myeloid Immunotherapy for Unresectable Pancreatic Cancer

IGNITE: A Phase 2 Study of Maintenance Combinatorial Myeloid Immunotherapy in Patients With Unresectable Pancreatic Ductal Adenocarcinoma


Sponsor

University of Pennsylvania

Enrollment

100 participants

Start Date

Nov 25, 2025

Study Type

INTERVENTIONAL

Conditions

Summary

Phase II, open-label, single-arm study of CD40/Dectin-1 immunotherapy as maintenance treatment in patients with unresectable pancreatic ductal adenocarcinoma (PDA) who have not progressed following 4-6 months of first line (1L) chemotherapy.


Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study is testing a maintenance immunotherapy combination for people with unresectable (cannot be surgically removed) or metastatic pancreatic cancer who have already completed first-line chemotherapy and achieved stable disease or a partial response. The goal is to keep the cancer in check for longer after chemotherapy ends. **You may be eligible if...** - You are 18 or older with confirmed pancreatic cancer that cannot be removed surgically or has spread - You have completed 16–24 weeks of standard first-line chemotherapy and your cancer has not progressed - Your cancer showed at least stable disease or partial shrinkage after chemotherapy - You are able to understand the study and provide written consent **You may NOT be eligible if...** - Your cancer has progressed during or after first-line chemotherapy - Your organ function is not adequate to receive the study treatment - You do not meet other health-related requirements set by the study protocol Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGOdetiglucan

Odetiglucan 4 mg/kg IV every 3 weeks

DRUGMitazalimab

Mitazalimab 0.9 mg/kg IV every 3 weeks


Locations(1)

Hospital of the University of Pennsylvania

Philadelphia, Pennsylvania, United States

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NCT07199764


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