RecruitingNot ApplicableNCT07200518

Effect of Probiotics After Neurosurgery

The Multistrain Probiotic OMNi-BiOTiC® Hetox for Treatment After Neurosurgery (ProSURG)


Sponsor

University Maribor

Enrollment

110 participants

Start Date

Nov 3, 2025

Study Type

INTERVENTIONAL

Conditions

Summary

The goal of this randomised controlled trial is to determine the effect of consuming a multistrain probiotic OMNi-BiOTiC® Hetox on improving the healing, pain management, and postsurgical complications after neurosurgery. The main question it aims to answer is: • Is the multistrain probiotic OMNi-BiOTiC® Hetox effective in in improving patient-reported disability after neurosurgery? Researchers will compare the probiotic group and the placebo group to determine if the healing is significantly different between the groups.


Eligibility

Min Age: 18 Years

Inclusion Criteria4

  • adults with MRI-confirmed disc herniation, stenosis, or instability of the lumbar or cervical spine.
  • Able to provide written informed consent
  • Willing to comply with study procedures and follow-up assessments
  • No contraindications to probiotic administration

Exclusion Criteria3

  • symptoms of acute infection (vomiting, fever above 38°C, diarrhea, respiratory symptoms),
  • chronic diseases,
  • use of probiotics one month before inclusion.

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Interventions

DIETARY_SUPPLEMENTOMNi-BiOTiC® Hetox multistrain probiotic

OMNi-BiOTiC® Hetox multistrain probiotic

DIETARY_SUPPLEMENTPlacebo

Placebo


Locations(1)

University Medical Centre Maribor

Maribor, Slovenia

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NCT07200518