RecruitingNot ApplicableNCT07202039
Electronic Cigarettes as a Harm Reduction Strategy Among People With Opioid Use Disorder on Buprenorphine
Sponsor
Prisma Health-Upstate
Enrollment
90 participants
Start Date
Apr 29, 2026
Study Type
INTERVENTIONAL
Conditions
Summary
This project aims to investigate the impact of e-cigarette flavors and usage patterns on achieving harm-reduction milestones in a sample of cigarette smokers with opioid use disorder who are taking buprenorphine
Eligibility
Min Age: 21 Years
Inclusion Criteria10
- Age ≥21 years
- Smoke ≥5 CPD for ≥1 year
- Daily CC smoker
- Willing to switch to EC
- Exhaled CO ≥6 ppm
- Diagnosed with OUD
- Stable on bupropion treatment
- In good physical and mental health
- Able to use a smartphone
- Willing to participate in all study components
Exclusion Criteria11
- Interested in quitting CC (contemplation stage of change)
- Use of EC on ≥4 of the past 30 days
- Use of other tobacco products (e.g., cigars, smokeless tobacco) on ≥9 days of the past 30 days
- Use of nicotine replacement therapy, smoking cessation medication, or a cessation attempt in the past 30 days
- Hypertension
- Medical condition that would contraindicate participation
- Meet DSM-V criteria for major depressive episode, psychotic episode, or manic episode
- Current suicidal ideation or suicide attempt in the past year
- Psychiatric hospitalization in the past year
- Contemplating pregnancy, currently pregnant, or breastfeeding
- Unable to speak and/or read English
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Interventions
BEHAVIORALBrief individual counseling sessions
Five brief, individual counseling sessions will provide education, behavioral support, and motivational strategies to facilitate switching from combustible cigarette use to EC
Locations(1)
View Full Details on ClinicalTrials.gov
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NCT07202039