Early Prediction of Neoadjuvant Chemotherapy Response in Bladder Cancer Using Quantitative Multiparametric MRI

This study is investigating whether advanced MRI scans — taken at specific points during chemotherapy — can predict early on whether the treatment is working in people with muscle-invasive bladder cancer. The goal is to better guide treatment decisions without waiting until after chemotherapy is complete. **You may be eligible if...** - You have been diagnosed with muscle-invasive bladder cancer (stage cT2 to cT4) - You are scheduled to receive cisplatin-based chemotherapy before bladder removal surgery - You are willing to undergo three MRI scans at different time points during treatment **You may NOT be eligible if...** - You have already had pelvic radiation therapy - You have severe kidney problems - You have had prior pelvic surgery - Your cancer has already spread to distant parts of the body at the time of diagnosis - You cannot have MRI scans for any medical reason - You are not eligible to receive cisplatin Talk to your doctor to see if this trial is right for you.