Efficacy of Targeted Drugs Combined With Chemotherapy in the Treatment of T-ALL

This study is testing a new combination of targeted drugs and chemotherapy for adults with a rare and aggressive blood cancer called T-cell acute lymphoblastic leukemia (T-ALL). The goal is to find more effective treatment options for people who have just been diagnosed and have not yet received any treatment. **You may be eligible if...** - You are 18 or older and have been newly diagnosed with T-ALL based on bone marrow testing - You have never received any treatment for leukemia before - Your overall health and ability to function is rated as adequate (ECOG 0–2) - Your heart, liver, and kidney function meet the required levels - You have enough bone marrow sample available for genetic testing **You may NOT be eligible if...** - You have a different type of leukemia - You have previously received any cancer treatment - You have had a stem cell or bone marrow transplant before - You have another active cancer - You have uncontrolled heart disease, severe infection, or bleeding problems - You have a known allergy to any drugs used in this study - Your heart pumping function (ejection fraction) is below 50% Talk to your doctor to see if this trial is right for you.