RecruitingNCT07203768

A ELN-Multicenter Study on Phenotypic Evolution and Clinical Outcomes

Unmasking Polycythemia Vera in Long-Standing Essential Thrombocythemia: A ELN-Multicenter Study on Phenotypic Evolution and Clinical Outcomes

Sponsor

FROM- Fondazione per la Ricerca Ospedale di Bergamo- ETS

Enrollment

678 participants

Start Date

Dec 1, 2025

Study Type

OBSERVATIONAL

Conditions

Polycythemia Vera Thrombocythemia

Summary

International multicenter retrospective observational study consisting of two parts: a nested case-control study (part A) and a comparative retrospective cohort study (part B).

Eligibility

Min Age: 18 YearsMax Age: 100 Years

Inclusion Criteria1

\- ET patients (diagnosed according to "International consensus classification of myeloid neoplasms and acute leukemias - 2022" criteria) who are JAK2V617F positive and have progressed to PV (diagnosed according to "International consensus classification of myeloid neoplasms and acute leukemias - 2022" criteria) by 31/12/2020. The date of PV diagnosis will be defined as the index date and this group of patients will be defined as ET-to-PV cases.

Exclusion Criteria1

None.

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Locations(25)

Mayo Clinic

Rochester, Minnesota, United States

University Hospital Halle

Halle, Germany

Hannover Medical School

Hanover, Germany

University Clinic for Hematology, Oncology, Hemostaseology and Palliative Care Johannes Wesling Medical Center

Minden, Germany

Divisione Ematologia, Fondazione IRCCS Policlinico San Matteo

Pavia, Lombardy, Italy

Divisione Ematologia, Ospedale San Bortolo

Vicenza, Veneto, Italy

A.S.O. SS. Antonio e Biagio e C.Arrigo, SC Ematologia

Alessandria, Italy

ASST Papa Giovanni XXIII, SC Ematologia

Bergamo, Italy

ASST-Spedali Civili

Brescia, Italy

Ospedale Businco

Cagliari, Italy

AOU Policlinico Vittorio Emanuele - PO Gaspare Rodolico

Catania, Italy

AOU Careggi, Divisione di Ematologia

Florence, Italy

ASST Grande Ospedale Metropolitano Niguarda, Divisione di Ematologia

Milan, Italy

Fondazione IRCCS Cà Grande - Op. Maggiore Policlinico

Milan, Italy

Ospedale San Raffaele

Milan, Italy

ASST MONZA Ospedale San Gerardo Clinica Ematologica

Monza, Italy

Azienda Ospedaliera Universitaria Federico II di Napoli Divisione di Ematologia e Trapianti del Midollo

Naples, Italy

Azienda Ospedaliero Universitaria Maggiore della Carità di Novara SCDU Ematologia

Novara, Italy

Presidio Ospedaliero di Pescara

Pescara, Italy

Fondazione Policlinico Universitario Gemelli

Roma, Italy

Umberto I Policlinico

Roma, Italy

Azienda Ospedaliera Universitaria Integrata - Ospedale Borgo Roma, Unità di Ematologia

Verona, Italy

IDIBAPS, Hospital clinic

Barcelona, Spain

12 Octubre University Hospital

Madrid, Spain

Guy's and St. Thomas' NHS Foundation Trust

London, United Kingdom

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