RecruitingPhase 3NCT07210515

Evaluation of IV AMBTX-01 (Neridronate) for Treatment of CRPS Type 1 (CRPS-RISE)

A Randomized, Triple-blind, Placebo-controlled, Phase 3 Trial to Evaluate the Efficacy, Safety, and Tolerability of Intravenous AMBTX-01 (Neridronate) for Treatment of Complex Regional Pain Syndrome Type 1 (CRPS-RISE)

Sponsor

Ambros Therapeutics, Inc.

Enrollment

270 participants

Start Date

Apr 14, 2026

Study Type

INTERVENTIONAL

Conditions

Complex Regional Pain Syndrome Type I

Summary

Phase 3 Trial of AMBTX-01 (neridronate) for Complex Regional Pain Syndrome Type 1

Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This clinical trial is studying a drug called Neridronate and a drug called Placebo for people with complex regional pain syndrome type i. The study is currently recruiting participants at 10 locations. People eligible for this study include aged 18 Years and older.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGNeridronate

neridronate 100 mg, given as a 2-hour infusion on Days 1, 4, 7, and 10.

DRUGPlacebo

placebo comparator

Locations(19)

Ambros Clinical Trial Site

Phoenix, Arizona, United States

Ambros Clinical Trial Site

Tucson, Arizona, United States

Ambros Clinical Trial Site

Napa, California, United States

Ambros Clinical Trial Site

Pasadena, California, United States

Ambros Clinical Trial Site

Tustin, California, United States

Ambros Clinical Trial Site

Washington D.C., District of Columbia, United States

Ambros Clinical Trial Site

Brandon, Florida, United States

Ambros Clinical Trial Site

Daytona Beach, Florida, United States

Ambros Clinical Trial Site

Pembroke Pines, Florida, United States

Ambros Clinical Trial Site

Lawrenceville, Georgia, United States

Ambros Clinical Trial Site

Newnan, Georgia, United States

Ambros Clinical Trial Site

Chicago, Illinois, United States

Ambros Clinical Trial Site

Orland Park, Illinois, United States

Ambros Clinical Trial Site

Reno, Nevada, United States

Ambros Clinical Trial Site

Shrewsbury, New Jersey, United States

Ambros Clinical Trial Site

Charlotte, North Carolina, United States

Ambros Clinical Trial Site

Wilmington, North Carolina, United States

Ambros Clinical Trial Site

Winston-Salem, North Carolina, United States

Ambros Clinical Trial Site

Houston, Texas, United States

View Full Details on ClinicalTrials.gov

For the most up-to-date information, visit the official listing.

Visit

NCT07210515

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