RecruitingPhase 1NCT07211659

Trial of THEO-260 (Administered Via Intraperitoneal Route) in Ovarian Cancer Patients

A Phase I, Open-label, Dose Finding, Safety, Tolerability and Exploratory Trial of THEO-260 Administered Via an Intraperitoneal Route in Patients With High Grade Serous or Endometrioid Ovarian Cancer


Sponsor

Theolytics Limited

Enrollment

18 participants

Start Date

Feb 13, 2026

Study Type

INTERVENTIONAL

Conditions

Summary

A research study evaluating a new oncolytic virus, THEO-260, in patients with advanced ovarian cancer. The trial will investigate different doses of THEO-260 administered by the intraperitoneal route to identify a dose that is safe, well tolerated, and exhibits preliminary evidence of anti tumour activity.


Eligibility

Sex: FEMALEMin Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study tests THEO-260, a new drug delivered directly into the abdominal cavity (intraperitoneally), for women with advanced ovarian, fallopian tube, or peritoneal cancer whose cancer has stopped responding to platinum-based chemotherapy. **You may be eligible if...** - You have advanced high-grade serous or endometrioid ovarian, fallopian tube, or primary peritoneal cancer confirmed by biopsy - Your cancer has progressed during or within 6 months of platinum chemotherapy (platinum-resistant or refractory) - Your life expectancy is more than 6 months - Your blood counts and organ function meet required thresholds - You are not pregnant or breastfeeding, and you are post-menopausal or using effective contraception **You may NOT be eligible if...** - Your cancer is not platinum-resistant or refractory - You have had too many prior lines of treatment (as determined by the study team) - Your organ function is significantly impaired Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

BIOLOGICALTHEO-260

Oncolytic virus


Locations(1)

MD Anderson Cancer Center

Houston, Texas, United States

View Full Details on ClinicalTrials.gov

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NCT07211659


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