RecruitingPhase 2Phase 3NCT07213375

High Dose Dexamethasone to Reduce Postoperative Pain After Video-Assisted Thoracoscopic Surgery Lobectomy /Segmentectomy

High Dose Dexamethasone In High-Pain Responders Undergoing Enhanced Recovery Video-Assisted Thoracoscopic Surgery Lobectomy and Segmentectomy - A Randomized Double-Blinded Controlled Trial


Sponsor

Rigshospitalet, Denmark

Enrollment

80 participants

Start Date

Sep 1, 2025

Study Type

INTERVENTIONAL

Conditions

Summary

The aim is to conduct a randomized controlled trial (RCT) with a high dose arm (1mg/kg) vs a low dose (8mg in total) of steroid (Dexamethasone) given intravenous (IV) after the induction of anesthesia to "High-pain-responders" in patients undergoing VATS lobectomy/segmentectomy. The hypothesis is that a high dose of Dexamethasone can lower pain when coughing in the morning after VATS lobectomy/segmentectomy, in patients scoring as "High-pain-responders" on the Pain-Catastrophizing-Scale


Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study is testing whether a single high dose of dexamethasone (a steroid used to reduce inflammation) given before lung surgery can reduce pain in the days following a minimally invasive lung removal procedure (video-assisted thoracoscopic surgery, or VATS). **You may be eligible if...** - You are 18 years old or older - You are scheduled for elective lung lobe or segment removal using VATS - You have significant expected postoperative pain (score of 20 or higher on a pain scale) - You can read and speak Danish **You may NOT be eligible if...** - You are already taking steroids or immune-suppressing medications (not counting inhalers) - You have diabetes requiring insulin - You are pregnant or breastfeeding - You have a known allergy to the study drug - You have schizophrenia, active psychosis, or bipolar disorder - You regularly take opioid pain medications - You have conditions affecting how you feel pain (e.g., spinal cord injury or severe nerve damage) Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGDexamethasone

Patients will receive either low dose (8mg) or high dose (1mg/kg)


Locations(1)

Department for Cardiothoracic Surgery, Rigshospitalet

Copenhagen, Copenhagen, Denmark

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NCT07213375


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