RecruitingNCT07214753

A Real-life Observational Study in Severe Eosinophilic Asthma Adult Participant Treated With Benralizumab in Italy

ItAlian, Multicenter, Observational, Prospective sTudy to Evaluate the acHievement of Clinical rEmission and immuNomodulation in Severe Eosinophilic Asthma Patients Treated With Benralizumab - the ATHENA Study


Sponsor

AstraZeneca

Enrollment

335 participants

Start Date

Dec 20, 2025

Study Type

OBSERVATIONAL

Conditions

Summary

This is an observational, multicenter, prospective study on patients with severe eosinophilic asthma treated with benralizumab aimed at evaluating the achievement of partial and complete clinical remission.


Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This Italian observational study is collecting real-world data on adults with severe uncontrolled eosinophilic asthma (a type of asthma driven by high levels of a white blood cell called eosinophils) who are starting treatment with benralizumab, an approved biologic injection. **You may be eligible if...** - You are 18 or older and have been diagnosed with severe uncontrolled eosinophilic asthma - Your doctor has prescribed benralizumab as part of your regular care (within 7 days before or after enrollment) - You are starting benralizumab for the first time (or have not received it in the past 12 months) **You may NOT be eligible if...** - You have received benralizumab in the past 12 months - You are currently in or recently completed another clinical trial - You have a contraindication to benralizumab - You are pregnant or breastfeeding - You have been recently treated with other biologic asthma medications without an adequate washout period Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

BIOLOGICALbenralizumab

30mg s.c. as per SmPC


Locations(28)

Research Site

Salerno, Battipaglia, Italy

Research Site

Padova, Cittadella, Italy

Research Site

Teramo, Giulianova, Italy

Research Site

Treviso, Montebelluna, Italy

Research Site

Varese, Tradate, Italy

Research Site

Bari, Italy

Research Site

Bergamo, Italy

Research Site

Bologna, Italy

Research Site

Bologna, Italy

Research Site

Brescia, Italy

Research Site

Catania, Italy

Research Site

Catanzaro, Italy

Research Site

Florence, Italy

Research Site

Foggia, Italy

Research Site

Messina, Italy

Research Site

Milan, Italy

Research Site

Modena, Italy

Research Site

Naples, Italy

Research Site

Naples, Italy

Research Site

Padova, Italy

Research Site

Palermo, Italy

Research Site

Pavia, Italy

Research Site

Roma, Italy

Research Site

Roma, Italy

Research Site

Sassari, Italy

Research Site

Siena, Italy

Research Site

Torino, Italy

Research Site

Verona, Italy

View Full Details on ClinicalTrials.gov

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NCT07214753